Review of Synbiotic 365 from United Naturals

Review Rating:

Best for: Digestive Health

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Review Summary

United Naturals is a digestive health company started in 2017 by a Canadian founder. Their first product is Synbiotic 365 which contains a novel blend of probiotics, prebiotics and B vitamins.

Based on my 9 years running, this is one the most carefully researched probiotic blends I’ve ever found. It’s well suited to digestive health, plus it supports vitamin B deficiencies that are common in people with digestive issues.

Synbiotic 365 is a very innovative “3-in-1” product for digestive health.

Video Review of Synbiotic 365

What Was The Inspiration For Creating Sybiotic 365?

I interviewed the Canadian founder of United Naturals about how he become interested in digestive health. He said that his initial interest in digestive health came from his girlfriend who was having life-destroying digestive issues.

He started looking into what might help her digestive health, and landed on probiotics. Laboratory testing also found that her vitamin B levels (B12 and B6 were most deficient) were quite depleted. And because she was having issues digesting vegetables containing prebiotics, her digestive health was further boosted by taking a prebiotic.

United Natural’s Formula Was Perfected By Dr. Vincent Pedre

Even though this combination of probiotics/prebiotics/B vitamins worked well for his girlfriend digestive issues, United Natural’s founder wanted to make sure it was the perfect digestive health formula. So he teamed up with Dr. Vincent Pedre out of New York to perfect the the Sybiotic 365 formula.

Dr. Vincent Pedre specializes in internal medicine and was educated at Cornell university. Dr. Vincent Pedre brought out his extensive medical knowledge and experience to create the optimum digestive health formula. This new formula reflects the latest probiotic and digestive research. And this product may be your best chance for better digestive health.

Ingredients in Synbiotic 365

In this part of the review we’re going to break down every single ingredient that this product has.

Probiotics in This Product

I’m very impressed with the large range of highly research probiotic strains in this product. I’ll go over the dosage and individual strains below.

30 Billion CFU Per Capsule

This United Naturals probiotic has 30 Billion CFU in each capsule. And if you’ve downloaded our probiotics buying guide, you know that that’s a great starting dose of probiotics.

This “Goldilocks CFU” is the highest dose I recommend to people buying their first probiotic…it’s a good dose that reduces the chance of side effects, yet it’s strong enough for most people to have symptomatic relief. And if someone wants a higher dose, they can take multiple capsules, spaced throughout the day.

Contains 14 Proven Probiotic Strains

This product has 14 different probiotic strains in it. Each one of these strains is extensively researched and have research supported digestive health benefits. Additionally, many of these probiotic strains also have immunity and anti-allergy health benefits.

  • Lactobacillus acidophilus La-14™
  • Bifidobacterium lactis Bl-04™
  • Lactobacillus paracasei Lpc-37™
  • Lactobacillus plantarum Lp-115™
  • Streptococcus thermophilus St-21™
  • Lactobacillus casei Lc-11™
  • Lactobacillus reuteri
  • Lactobacillus salivarius Ls-33™
  • Lactobacillus rhamnosus Lr-32™
  • Lactobacillus gasseri Lg-36™
  • Lactobacillus fermentum
  • Bifidobacterium bifidum Bb-06™
  • Bifidobacterium longum Bl-05™
  • Saccharomyces boulardii


This product contains 350 mg of chicory root inulin. This is a high quality plant derived prebiotic and is very well researched.

B Vitamins

An extremely common B vitamin deficiency for people who have digestive issues is B12 deficiency. Because of that, Sybiotics 365 has 1000% of the daily value of this nutrient.

For the following B vitamins, this product contains 200% of the daily value:

  • B1 – 200% DV
  • B2 – 200% DV
  • B3 – 200% DV
  • B5 – 200% DV
  • B6 – 200% DV
  • B7 – 200% DV
  • B9 – 200% DV

People can have all sorts of health problems from thinning hair, all the way to extreme fatigue by being deficient in B vitamins. So I like that this product supports those aspects of our health as well.

Other ingredients

The inactive ingredients are hypromellose and rice hull concentrate.

I know for a fact rice hull concentrate is safe unless you have a rice allergy which is quite rare.

I looked into hypromellose and I couldn’t find any credible evidence that there is anything unsafe about it. There were some crazy hippie blogs saying it was bad, but those blogs did not show any evidence or sources for why it is bad or unhealthy. I took this product and didn’t notice any effects myself.

Synbiotic 365 Allergen Information

United Naturals made this probiotic to be consumable for people with food allergies and sensitives. Please see the allergen information below.

Gluten Free Probiotic – Taken By People With Celiac Disease

The founder told me that this product is gluten free, and people with Celiac’s disease have not had negative reactions to the product. I have a very good friend with Celiac’s disease, so I’m glad he can take this product without fear.

Dairy Free Probiotic – Okay for Dairy Intolerant People

This product contains no diary or lactose. The manufacturer of this product says that some dairy is used in culturing the probiotic strains. But only extremely trace levels of dairy should be present. The founder says that there have been no complaints or issues for people who are dairy free.

No Soy, Eggs or Nuts in this product

There aren’t any eggs, nuts or soy in this product. There is also no cross-contamination of these allergens.

Synbiotic 365 is GMO Free

None of the ingredients in this supplement contain genetically modified organisms (GMO’s).

What Is The Synbiotic 365 Starting Dosage?

The starting dosage for Sybiotic 365 is just 1 capsule per day. I like to take the capsule on an empty stomach with 8oz of water.

Do They Offer A Money Back Guarantee?

Yes! I really respect companies that give a money back guarantee. That shows that the company believes 100% in their product. And for you, there is no risk in trying this product.

Are There Any Synbiotic 365 Scams?

The internet is a big place, and there is always a chance people are counterfeiting the product or running another type of scam. To avoid any chance of scams, buy directly from the company at

Any Product Complaints?

I didn’t have any issues with this product. The ingredients are clean and the research behind them looks sound. No complaints from me.

Does United Naturals Have Good Customer Support?

I called their company after hours, left a message and got a call back early the next day. I think that’s very responsive and reasonable.

Where Can You Purchase Synbiotics 365?

The best place to purchase this product is direct from the manufacturer. You can buy just 1 box, or, you can get a large discount by ordering ordering multiple boxes.

Review Rating:

Best for: Digestive Health

Click here to buy direct (best price)

No Risk – 60 day money back guarantee

48 comments on “Synbiotic 365 Review – Probiotic By United Naturals” - Click here to write your comment

  1. Orrin Doxer says:

    I just purchased a large supply of Synbiotic 365 and have taken 1 per day for the past 5 days. I stopped Prilosec and all other antacids. I have a long history of ulcers, gerd, stress, anxiety and overeating. Basically that’s all in the past. I’m 76 and in good health. I exercise regularly, eat healthy but still have night time munchies. I’m feeling very positive about using Synbiotic. Is there any benefit to increasing my dosage by adding one more pill per day?

    • evan says:

      Hi Orrin,

      There is a greater risk of probiotic side effects by taking more than 1 pill per day. But, if it works for you without side effects, I say full steam ahead.

      Evan Jerkunica

  2. DiAnne Slater says:

    Just ordered Dr. Vincent Pedre’s Symbiotic 365. Many reviews about this probiotics were mostly neutral. Did see one ingredient, cyanide (shortened term) causing concern from one reviewer. After reading several reviews, I like yours best. Looks like @ 880 + views so far. I’m motivated to give Symbiotic 365 a fair trial for 90-Days. Time will tell. “I gut this!”

    • evan says:

      Hi DiAnne,

      I posted a picture of the ingredients…there is no cyanide lol.

      B12 is cyanocobalamin – not cyanide…
      B3 is niacinamide – also not cyanide…

      Reviewers need to have some scientific literacy – geeze.

      That’s like saying methylfolate is methamphetamine…when methylfolate is a great nutrient found in green leafy vegetables.

      Evan Jerkunica

  3. Julissa says:

    I just had a baby 3 months ago. I had c section, I already had problem on my stomach. But I’m worried that my problem came back it hurts on the left side thinking that is my instestines. My question is it save to drink while you are breast feeding. I used to drink Prilosec but since I’m breastfeeding I can’t take that type of meds. I just so much discomfort and I was thinking of trying this? It’s safe for kids as well?thanks

    • evan says:

      Hi Julissa,

      I would ask your doctor to make sure if it’s okay for you in your situation. I haven’t heard of any issues personally, but always check with your doctor.

      To your heath,
      Evan Jerkunica

  4. Rob Farkas says:

    how many doses are in a box?

  5. Gillian Rogers says:

    Hi Evan Is there anywhere in Canada that I can purchase this product?

  6. Dean Bratel says:

    Is this product safe to take daily long term. Can you ever get to much bacteria??

    • evan says:

      Hi Dean,

      I don’t think there are any known issues to taking a probiotic “long term”.

      I would be sure to address other lifestyle factors that affect your health as well though.

      To your health,
      Evan Jerkunica

  7. Carl says:

    Is it ok to take a daily multivitamin pill along with Symbiotic pill?

    • evan says:

      Hi Carl,

      The only way to say for sure is to ask a doctor. That doctor will know any medical conditions that you have, and he/she will know the exact multivitamin you are taking.

      Then, your doctor can make an informed decision.

      For most people I believe the negative risk of interaction is extremely low, but I can’t say for sure. You would have to speak with a doctor.

      To your health,
      Evan Jerkunica

  8. Mary S Brookover says:

    Is symbiotic 365 endorsed by a gut dr

    • evan says:

      Hi Mary S Brookover,

      Yes, Synbiotic 365 is endorsed by Dr. Vincent Pedre. Dr. Vincent Pedre specializes in internal medicine (and gut health is one aspect of that). He was educated at Cornell university.

      To your health,
      Evan Jerkunica

  9. Florence Johnson-bailey says:

    Is this product safe for kids? 13 yr old

    • evan says:

      Hi Florence Johnson-bailey,

      The only way to be sure is to ask your doctor.

      To me, the ingredients look safe for 13 year olds.

      But, I am not a doctor. So ask your doctor to be sure.

      To your health,
      Evan Jerkunica

  10. carol collins says:

    Will Synbiotic 365 interfere with the vitamins i’m already taking?

    • evan says:

      Hi Carol Collins,

      I don’t know what vitamins you are taking – so I can’t say for sure. To be 100% sure, ask your doctor.

      But, I can say is that the only possibility would be having too much of B vitamin complex. But the quantities of B vitamin are quite low compared to health problem doses listed on So I think the risk is extremely minimal.

      Again – to be sure, check with your doctor when taking new supplements. Especially if you have health problems already.

      To your health,
      Evan Jerkunica

  11. Dr. Gideon Nwatu says:

    How many tablets or capsules in 1 box?

  12. Jordan says:

    Hi I am 25 years old and am healthy allready. I am taking these to help with my general health and to possibly clear up my acne from bad bacteria in my body. Were i am young I was wondering if it is ok to take one of these supplements every 2 days instead of every day?

    • evan says:

      Hi Jordan,

      I would strongly recommend you begin with the recommended dose. Once your body gets accustomed to that dose, then you can take a second capsule – say every other day. Once you’ve done that, then you can up the dose to 2 capsules a day if you’re not getting any probiotic overdose effects.

      Remember that health is a marathon – not a sprint. Slow and steady will win the race to health.

      To your health,
      Evan Jerkunica

  13. Jojo says:

    I have been taking Synbiotic 365 for just over 30 days I started my second box three days ago and I like how this product is working in my body. My digestive system feels happy. I am overweight and have been for years and I noticed since I have been taking this product I do not require much to eat. Oh I eat something for breakfast and again at mid-day but then I am done. I might has a small snack fruit or some chocolate but my appetite has curved greatly. My energy level has increased also. I was planning to continue taking the product but should I stop at some point?

    • evan says:

      Hi Jojo,

      That’s a great question. And the short answer is that I don’t think there is any proven harm to taking a supplement like Synbiotic 365 long term. I know that anecdotally some health practitioners like to cycle probiotic supplements, say every 3 months. But I also know that anecdotally many patients don’t feel as well when they’re off those supplements…so they suffer until they go back onto the original supplement.

      I’m a big believer in trying to understand why a supplement is helping me, and then bring those things into my life through diet or lifestyle changes. If I can figure out what those things are, then I’ll replace the supplement with those new foods, exercise or lifestyle changes.

      To your health,
      Evan Jerkunica

  14. Dee Treybig says:

    I am on week 2 of using product and have already been blessed with reduced stomach bloating and not taking Prilosec anymore – I feel so much better. Question: how many calories and are there any carbs? Neither are listed on label and I track both.
    Thank you.

    • evan says:

      Hi Dee,

      I’m glad to hear you’re feeling better.

      I don’t think this product is a significant source of calories. Calories come in carbohydrates, fats and proteins…and this product doesn’t have any of those.

      To your health,
      Evan Jerkunica

  15. Rachel B says:

    Is this product safe while breastfeeding?

  16. Linda M Mickle says:

    I reordered 6 more boxes (for the significant savings of Synbiotic 365 which appears to help my slow intestines and therefore my bowel movements. I an fairly pleased with how this probiotic has helped with that issue. After I placed my order another page popped up to buy Enzyme 365. This came yesterday and I can’t remember what benefits this offers plus when should I take this supplement?

    • evan says:

      Hi Linda,

      Enzyme 365 is an enzyme that improves digestion of food for people who are deficient in some or all enzymes.

      I would personally take a capsule in the middle of a meal, but it’s best to go by the directions that are printed on the bottle.

      To your health,
      Evan Jerkunica

  17. Cecilia C. says:

    Is the preparation, including the capsule, vegetarian?

  18. PAM BAILEY says:

    If I started the 365 probiotics today, when can I safely stop taking omeprazole for acid reflux.

  19. brianna says:

    is it vegan

  20. David says:

    I have a 10 year old daughter who is currently taking antibiotics for atopic dermatitis, a condition she has suffered her entire life. Is she old enough to take this product?

    • evan says:

      Hi David,

      There are lots of research studies with children taking probiotics. But, your daughter’s case may be different, so I’d recommend checking with your doctor.

      To your daughter’s health,
      Evan Jerkunica

  21. patty says:

    I am interested in purchasing Synbiotic365
    I do take a lot of medications, plavix, 325 asprin, crestor, bystolic, accupril, ranexa, xanax, omeprazole, zofran, nitro sublingual and nitro patch, d3
    are any of these contraindicated with Synbiotic365?
    I am a cardiac patient 4xcabg plus 11 stents, anxiety, stomach and esophagus spasms.
    I’d like to order. I have the video on hold. I sure hope I can get an answer asap.

  22. Susan says:

    Can the Synbiotic 365 be kept in the fridge

    • evan says:

      Hi Susan,

      Yes it can. I would recommend either keeping it in the fridge or keeping it outside of the fridge. If you leave it out for an hour and then put it back in, then condensation can happen which can decrease the potency of the probiotic.

      It doesn’t matter if you do it a few times, but if you have large temperature swings every day, then that can affect the potency over time.

      To your health,
      Evan Jerkunica

  23. Jody Jean Jones says:

    Can you take synbiotic 365 along with Garcinia Cambodia. I also bought Enzyme 365.

    • evan says:

      Hi Jody,

      WebMD says Garcinia cambogia may interact badly with:

      • Asthma and allergy medicines such as Accolate and Singulair
      • Diabetes medicines, including pills and insulin
      • Iron, for anemia
      • Pain medicines
      • Prescriptions for psychiatric conditions
      • Statins, drugs that lower cholesterol
      • Warfarin, a blood thinner

      Probiotics, prebiotics and B vitamins are not listed as reacting badly with Garcinia cambogia. So I don’t think there are any known bad interactions with Synbiotic 365’s ingredients. But, to be safe, it’s always best to ask a doctor.

      To your health,
      Evan Jerkunica

  24. Gary Rose says:

    My name is Gary Rose I have Parkinson Disease for the last fourteen years. Do you have opinion that having a leaky gut could cause a lack of Dopamine to be produce to the brain. Does the Vagus Nerve have anything to do with having tremors.

    • evan says:

      Hi Gary,

      I’m sorry I don’t know. I would speak with a doctor or look for research studies on Parkinson’s disease.

      To your health,
      Evan Jerkunica

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