Review of Synbiotic 365 from United Naturals

Review Rating:

Best for: Weight Loss and Energy (Digestive Health as well)

Click here to buy direct (best price)

No Risk – 60 day money back guarantee

Transparency disclosure: for each person who buys this product by clicking a link on this page, Probiotics.org receives a small percentage of the sale. I would strongly recommend this product without compensation, but I want you to know all the potential motivations for Probiotics.org writing this review. Transparency rules!

Review Summary

United Naturals is a digestive health company started in 2017 by a Canadian founder. Their first product is Synbiotic 365 which contains a novel blend of probiotics, prebiotics and B vitamins.

Based on my 9 years running Probiotics.org, this is one the most carefully researched probiotic blends I’ve ever found. It’s well suited to digestive health, plus it supports vitamin B deficiencies that are common in people with digestive issues.

Synbiotic 365 is a very innovative “3-in-1” product for digestive health.

Video Review of Synbiotic 365

What Was The Inspiration For Creating Sybiotic 365?

I interviewed the Canadian founder of United Naturals about how he become interested in digestive health. He said that his initial interest in digestive health came from his girlfriend who was having life-destroying digestive issues.

He started looking into what might help her digestive health, and landed on probiotics. Laboratory testing also found that her vitamin B levels (B12 and B6 were most deficient) were quite depleted. And because she was having issues digesting vegetables containing prebiotics, her digestive health was further boosted by taking a prebiotic.

United Natural’s Formula Was Perfected By Dr. Vincent Pedre

Even though this combination of probiotics/prebiotics/B vitamins worked well for his girlfriend digestive issues, United Natural’s founder wanted to make sure it was the perfect digestive health formula. So he teamed up with Dr. Vincent Pedre out of New York to perfect the the Sybiotic 365 formula.

Dr. Vincent Pedre specializes in internal medicine and was educated at Cornell university. Dr. Vincent Pedre brought out his extensive medical knowledge and experience to create the optimum digestive health formula. This new formula reflects the latest probiotic and digestive research. And this product may be your best chance for better digestive health.

Ingredients in Synbiotic 365

synbiotic 365 now with L gasseri

In this part of the review we’re going to break down every single ingredient that this product has.

Probiotics in This Product

I’m very impressed with the large range of highly research probiotic strains in this product. I’ll go over the dosage and individual strains below.

20 Billion CFU Per Capsule

This United Naturals probiotic has 20 Billion CFU in each capsule. And if you’ve downloaded our probiotics buying guide, you know that that’s a great starting dose of probiotics.

This “Goldilocks CFU” is the highest dose I recommend to people buying their first probiotic…it’s a good dose that reduces the chance of side effects, yet it’s strong enough for most people to have symptomatic relief. And if someone wants a higher dose, they can take multiple capsules, spaced throughout the day.

Contains 15 Proven Probiotic Strains

This product has 15 different probiotic strains in it. Each one of these strains is extensively researched and have research supported digestive health benefits. Additionally, many of these probiotic strains also have immunity and anti-allergy health benefits.

  1. Lactobacillus gasseri BNR-17® (new weight control probiotic)
  2. OPTI-BIOME B subtilis MB-40
  3. Bifidobacterium lactis BIO-4™
  4. Lactobacillus paracasei Lpc-37™
  5. Lactobacillus plantarum Lp-115™
  6. Streptococcus thermophilus St-21™
  7. Lactobacillus casei Lc-11™
  8. Lactobacillus reuteri
  9. Lactobacillus salivarius Ls-33™
  10. Lactobacillus rhamnosus Lr-32™
  11. Lactobacillus gasseri Lg-36™
  12. Lactobacillus fermentum
  13. Bifidobacterium bifidum Bb-06™
  14. Bifidobacterium longum Bl-05™
  15. Saccharomyces boulardii

Prebiotics

This product contains 350 mg of chicory root inulin. This is a high quality plant derived prebiotic and is very well researched.

B Vitamins

An extremely common B vitamin deficiency for people who have digestive issues is B12 deficiency. Because of that, Sybiotics 365 has 1000% of the daily value of this nutrient.

For the following B vitamins, this product contains 200% of the daily value:

  • B1 – 200% DV
  • B2 – 200% DV
  • B3 – 200% DV
  • B5 – 200% DV
  • B6 – 200% DV
  • B7 – 200% DV
  • B9 – 200% DV

People can have all sorts of health problems from thinning hair, all the way to extreme fatigue by being deficient in B vitamins. So I like that this product supports those aspects of our health as well.

Other ingredients

The inactive ingredients are hypromellose and rice hull concentrate.

I know for a fact rice hull concentrate is safe unless you have a rice allergy which is quite rare.

I looked into hypromellose and I couldn’t find any credible evidence that there is anything unsafe about it. There were some crazy hippie blogs saying it was bad, but those blogs did not show any evidence or sources for why it is bad or unhealthy. I took this product and didn’t notice any effects myself.

Synbiotic 365 Allergen Information

United Naturals made this probiotic to be consumable for people with food allergies and sensitives. Please see the allergen information below.

Gluten Free Probiotic – Taken By People With Celiac Disease

The founder told me that this product is gluten free, and people with Celiac’s disease have not had negative reactions to the product. I have a very good friend with Celiac’s disease, so I’m glad he can take this product without fear.

Dairy Free Probiotic – Okay for Dairy Intolerant People

This product contains no diary or lactose. The manufacturer of this product says that some dairy is used in culturing the probiotic strains. But only extremely trace levels of dairy should be present. The founder says that there have been no complaints or issues for people who are dairy free.

No Soy, Eggs or Nuts in this product

There aren’t any eggs, nuts or soy in this product. There is also no cross-contamination of these allergens.

Synbiotic 365 is GMO Free

None of the ingredients in this supplement contain genetically modified organisms (GMO’s).

What Is The Synbiotic 365 Starting Dosage?

The starting dosage for Sybiotic 365 is just 1 capsule per day. I like to take the capsule on an empty stomach with 8oz of water.

Do They Offer A Money Back Guarantee?

Yes! I really respect companies that give a money back guarantee. That shows that the company believes 100% in their product. And for you, there is no risk in trying this product.

Are There Any Synbiotic 365 Scams?

The internet is a big place, and there is always a chance people are counterfeiting the product or running another type of scam. To avoid any chance of scams, buy directly from the company at https://www.UnitedNaturals.com

Any Product Complaints?

I didn’t have any issues with this product. The ingredients are clean and the research behind them looks sound. No complaints from me.

Does United Naturals Have Good Customer Support?

I called their company after hours, left a message and got a call back early the next day. I think that’s very responsive and reasonable.

Where Can You Purchase Synbiotics 365?

The best place to purchase this product is direct from the manufacturer. You can buy just 1 box, or, you can get a large discount by ordering ordering multiple boxes.

Review Rating:

Best for: Digestive Health

Click here to buy direct (best price)

No Risk – 60 day money back guarantee




213 comments on “Synbiotic 365 Review – Probiotic By United Naturals” - Click here to write your comment

  1. Orrin Doxer says:

    I just purchased a large supply of Synbiotic 365 and have taken 1 per day for the past 5 days. I stopped Prilosec and all other antacids. I have a long history of ulcers, gerd, stress, anxiety and overeating. Basically that’s all in the past. I’m 76 and in good health. I exercise regularly, eat healthy but still have night time munchies. I’m feeling very positive about using Synbiotic. Is there any benefit to increasing my dosage by adding one more pill per day?

    • evan says:

      Hi Orrin,

      There is a greater risk of probiotic side effects by taking more than 1 pill per day. But, if it works for you without side effects, I say full steam ahead.

      Best,
      Evan Jerkunica

  2. DiAnne Slater says:

    Hello
    Just ordered Dr. Vincent Pedre’s Symbiotic 365. Many reviews about this probiotics were mostly neutral. Did see one ingredient, cyanide (shortened term) causing concern from one reviewer. After reading several reviews, I like yours best. Looks like @ 880 + views so far. I’m motivated to give Symbiotic 365 a fair trial for 90-Days. Time will tell. “I gut this!”

    • evan says:

      Hi DiAnne,

      I posted a picture of the ingredients…there is no cyanide lol.

      B12 is cyanocobalamin – not cyanide…
      B3 is niacinamide – also not cyanide…

      Reviewers need to have some scientific literacy – geeze.

      That’s like saying methylfolate is methamphetamine…when methylfolate is a great nutrient found in green leafy vegetables.

      Best,
      Evan Jerkunica

  3. Julissa says:

    I just had a baby 3 months ago. I had c section, I already had problem on my stomach. But I’m worried that my problem came back it hurts on the left side thinking that is my instestines. My question is it save to drink while you are breast feeding. I used to drink Prilosec but since I’m breastfeeding I can’t take that type of meds. I just so much discomfort and I was thinking of trying this? It’s safe for kids as well?thanks

    • evan says:

      Hi Julissa,

      I would ask your doctor to make sure if it’s okay for you in your situation. I haven’t heard of any issues personally, but always check with your doctor.

      To your heath,
      Evan Jerkunica

  4. Rob Farkas says:

    how many doses are in a box?

  5. Gillian Rogers says:

    Hi Evan Is there anywhere in Canada that I can purchase this product?

  6. Dean Bratel says:

    Is this product safe to take daily long term. Can you ever get to much bacteria??

    • evan says:

      Hi Dean,

      I don’t think there are any known issues to taking a probiotic “long term”.

      I would be sure to address other lifestyle factors that affect your health as well though.

      To your health,
      Evan Jerkunica

  7. Carl says:

    Is it ok to take a daily multivitamin pill along with Symbiotic pill?

    • evan says:

      Hi Carl,

      The only way to say for sure is to ask a doctor. That doctor will know any medical conditions that you have, and he/she will know the exact multivitamin you are taking.

      Then, your doctor can make an informed decision.

      For most people I believe the negative risk of interaction is extremely low, but I can’t say for sure. You would have to speak with a doctor.

      To your health,
      Evan Jerkunica

  8. Mary S Brookover says:

    Is symbiotic 365 endorsed by a gut dr

    • evan says:

      Hi Mary S Brookover,

      Yes, Synbiotic 365 is endorsed by Dr. Vincent Pedre. Dr. Vincent Pedre specializes in internal medicine (and gut health is one aspect of that). He was educated at Cornell university.

      To your health,
      Evan Jerkunica

  9. Florence Johnson-bailey says:

    Is this product safe for kids? 13 yr old

  10. carol collins says:

    Will Synbiotic 365 interfere with the vitamins i’m already taking?

    • evan says:

      Hi Carol Collins,

      I don’t know what vitamins you are taking – so I can’t say for sure. To be 100% sure, ask your doctor.

      But, I can say is that the only possibility would be having too much of B vitamin complex. But the risk is considered pretty low healthline.com.

      Again – to be sure, check with your doctor when taking new supplements. Especially if you have health problems already.

      To your health,
      Evan Jerkunica

  11. Dr. Gideon Nwatu says:

    How many tablets or capsules in 1 box?

  12. Jordan says:

    Hi I am 25 years old and am healthy allready. I am taking these to help with my general health and to possibly clear up my acne from bad bacteria in my body. Were i am young I was wondering if it is ok to take one of these supplements every 2 days instead of every day?

    • evan says:

      Hi Jordan,

      I would strongly recommend you begin with the recommended dose. Once your body gets accustomed to that dose, then you can take a second capsule – say every other day. Once you’ve done that, then you can up the dose to 2 capsules a day if you’re not getting any probiotic overdose effects.

      Remember that health is a marathon – not a sprint. Slow and steady will win the race to health.

      To your health,
      Evan Jerkunica

  13. Jojo says:

    I have been taking Synbiotic 365 for just over 30 days I started my second box three days ago and I like how this product is working in my body. My digestive system feels happy. I am overweight and have been for years and I noticed since I have been taking this product I do not require much to eat. Oh I eat something for breakfast and again at mid-day but then I am done. I might has a small snack fruit or some chocolate but my appetite has curved greatly. My energy level has increased also. I was planning to continue taking the product but should I stop at some point?

    • evan says:

      Hi Jojo,

      That’s a great question. And the short answer is that I don’t think there is any proven harm to taking a supplement like Synbiotic 365 long term. I know that anecdotally some health practitioners like to cycle probiotic supplements, say every 3 months. But I also know that anecdotally many patients don’t feel as well when they’re off those supplements…so they suffer until they go back onto the original supplement.

      I’m a big believer in trying to understand why a supplement is helping me, and then bring those things into my life through diet or lifestyle changes. If I can figure out what those things are, then I’ll replace the supplement with those new foods, exercise or lifestyle changes.

      To your health,
      Evan Jerkunica

  14. Dee Treybig says:

    I am on week 2 of using product and have already been blessed with reduced stomach bloating and not taking Prilosec anymore – I feel so much better. Question: how many calories and are there any carbs? Neither are listed on label and I track both.
    Thank you.

    • evan says:

      Hi Dee,

      I’m glad to hear you’re feeling better.

      I don’t think this product is a significant source of calories. Calories come in carbohydrates, fats and proteins…and this product doesn’t have any of those.

      To your health,
      Evan Jerkunica

  15. Rachel B says:

    Is this product safe while breastfeeding?

  16. Linda M Mickle says:

    I reordered 6 more boxes (for the significant savings of Synbiotic 365 which appears to help my slow intestines and therefore my bowel movements. I an fairly pleased with how this probiotic has helped with that issue. After I placed my order another page popped up to buy Enzyme 365. This came yesterday and I can’t remember what benefits this offers plus when should I take this supplement?
    Thanks.
    Linda

    • evan says:

      Hi Linda,

      Enzyme 365 is an enzyme that improves digestion of food for people who are deficient in some or all enzymes.

      I would personally take a capsule in the middle of a meal, but it’s best to go by the directions that are printed on the bottle.

      To your health,
      Evan Jerkunica

  17. Cecilia C. says:

    Is the preparation, including the capsule, vegetarian?

  18. PAM BAILEY says:

    If I started the 365 probiotics today, when can I safely stop taking omeprazole for acid reflux.

  19. brianna says:

    is it vegan

  20. David says:

    I have a 10 year old daughter who is currently taking antibiotics for atopic dermatitis, a condition she has suffered her entire life. Is she old enough to take this product?

    • evan says:

      Hi David,

      There are lots of research studies with children taking probiotics. But, your daughter’s case may be different, so I’d recommend checking with your doctor.

      To your daughter’s health,
      Evan Jerkunica

  21. patty says:

    I am interested in purchasing Synbiotic365
    I do take a lot of medications, plavix, 325 asprin, crestor, bystolic, accupril, ranexa, xanax, omeprazole, zofran, nitro sublingual and nitro patch, d3
    are any of these contraindicated with Synbiotic365?
    I am a cardiac patient 4xcabg plus 11 stents, anxiety, stomach and esophagus spasms.
    I’d like to order. I have the video on hold. I sure hope I can get an answer asap.

  22. Susan says:

    Can the Synbiotic 365 be kept in the fridge

    • evan says:

      Hi Susan,

      Yes it can. I would recommend either keeping it in the fridge or keeping it outside of the fridge. If you leave it out for an hour and then put it back in, then condensation can happen which can decrease the potency of the probiotic.

      It doesn’t matter if you do it a few times, but if you have large temperature swings every day, then that can affect the potency over time.

      To your health,
      Evan Jerkunica

  23. Jody Jean Jones says:

    Can you take synbiotic 365 along with Garcinia Cambodia. I also bought Enzyme 365.

    • evan says:

      Hi Jody,

      WebMD says Garcinia cambogia may interact badly with:

      • Asthma and allergy medicines such as Accolate and Singulair
      • Diabetes medicines, including pills and insulin
      • Iron, for anemia
      • Pain medicines
      • Prescriptions for psychiatric conditions
      • Statins, drugs that lower cholesterol
      • Warfarin, a blood thinner

      Probiotics, prebiotics and B vitamins are not listed as reacting badly with Garcinia cambogia. So I don’t think there are any known bad interactions with Synbiotic 365’s ingredients. But, to be safe, it’s always best to ask a doctor.

      To your health,
      Evan Jerkunica

  24. Gary Rose says:

    My name is Gary Rose I have Parkinson Disease for the last fourteen years. Do you have opinion that having a leaky gut could cause a lack of Dopamine to be produce to the brain. Does the Vagus Nerve have anything to do with having tremors.

    • evan says:

      Hi Gary,

      I’m sorry I don’t know. I would speak with a doctor or look for research studies on Parkinson’s disease.

      To your health,
      Evan Jerkunica

  25. Sasha says:

    Is it safe to take 365 when you have diabetes?

    • evan says:

      Hi Sasha,

      You should ask your doctor. I haven’t heard of any bad interactions between diabetes and probiotics/prebiotics/b vitamins, but always ask your doctor to be sure.

      To your health,
      Evan Jerkunica

  26. Wes says:

    I bought Synbiotic 365 and Enzyme 365 but didn’t get get equal qty. I don’t see where to buy refills of just Enzyme 365. Ideas?

  27. Maurice says:

    hi, My name is Maurice and I was wondering if the United Naturals product is safe. I was looking into your product and I saw that “United naturals” was not listed as a certified company with the “Better Business Bureau” I was wondering why they aren’t certified.

    • evan says:

      Hi Maurice,

      I can tell you that my dealings with the founder have been good. They honor their return policy and have a very good bunch of products.

      I will suggest to the founder that he should get certified with the BBB.

      To your health,
      Evan Jerkunica

  28. Barbara Brody says:

    Are there any mushrooms in this product? I am allergic to them.

  29. May Knisley says:

    hOW MUCH DOES TJHIS PRODUCT COST?

  30. Millicent Maloney says:

    I would like to try the Synbiotic 365 but I am currently thanking blood pressure and cholesterol medications.How would synbiotic react with these meds..

  31. Faye says:

    I takeAlign which is a probiotic supplement should I discontinue this since I just started Syn. 365?

  32. Sharon says:

    Does this product help in weight loss? Can it be used for weight loss? Does it curb the appetite or burn fat in the body?

    • evan says:

      Hi Sharon,

      There is evidence that probiotics can help with weight loss.

      But, I don’t think this company claims that.

      That being said, I have read some customer testimonials where Synbiotic 365 customers said they lost over 5 lbs of weight after starting to take this product.

      To your health,
      Evan Jerkunica

  33. John Dell'Isola says:

    Can you mix this product if your taking other medications?

  34. Gabriela says:

    Hi,
    I am really interested in your product, do you deliver to Canada?

  35. Frank says:

    I have read that it is more important to take prebiotic to feed your probiotics ! That taking probiotics is a waste of time and money, if they can’t feed on prebiotics ?

    • evan says:

      Hi Frank,

      This product contains prebiotics.

      A probiotics product doesn’t has to have prebiotics to be effective. With the right diet, you can get enough prebiotics. But few people eat that way!

      To your health,
      Evan Jerkunica

  36. Sarah says:

    Does it contain iodine or seafood product?

  37. Sandra. says:

    Hi, when is the best time to take this pill? Morning or nights? Thanks.

    • evan says:

      Hi Sandra,

      I would take it on an empty stomach, first thing in the morning.

      You can also try taking it right after you’ve had breakfast…but I would generally take it first thing in the morning.

      To your health,
      Evan Jerkunica

  38. Vanessa says:

    My name is Vanessa I would like to get this for my daughter and son but I would like to speak to someone

  39. Happy says:

    Hi,

    I would like to try this product but I would like to know the ingredients. Does this product contain garlic or onion in any form? Is it purely vegan?

    Thank you

  40. Janey says:

    Hello,

    I was wondering if’s pregnant women can take this probiotic?

    Thank you!

    • evan says:

      Hi Janey,

      There are research studies with pregnant women using probiotics safely.

      But, you should always ask your doctor if it’s okay for you to take a supplement. You could have specific health conditions that make it a bad idea for you to take certain supplements.

      To your health,
      Evan Jerkunica

  41. Kathe says:

    I am taking and have been taking a prebiotic for over a year. They have taken heart burn away completely. I stoped all ainacids, I did purchase 6 month supply of symbiotic 365 and want to try them. Should I take them with or without my prebiotic.

    • evan says:

      Hi Kathe,

      Synbiotic 365 has a prebiotic in it. So if you took your normal prebiotic with it, then you could have too much prebiotic. Too much prebiotic can cause bloating.

      I would try just taking the Synbiotic 365 by itself. Then, after a few weeks, I would add in the prebiotic every other day. If you still felt okay, you could take the prebiotic every day.

      You’ll have to experiment a bit and find what works for you.

      To your health,
      Evan Jerkunica

  42. Valdoria says:

    Was interested until I noticed the B vitamins are synthetic and not bioavailable for the body. This is the cheap version of B12, Cyanocobalamin. I expected the higher quality Methylcobalamin or Hydroxycobalamin.

    • evan says:

      Hi Valdoria,

      I just spoke with the manufacturer, and they use Methylcobalamin.

      I’ve updated the review article to reflect that!

      Thank you for pointing that out.

      To your health,
      Evan Jerkunica

  43. Matonna Lutes says:

    I cannot swallow pills. Could I open the capsules and mix with something?

    • evan says:

      Hi Matonna,

      Yes – that should be okay. You want to mix it with cold water – not hot or boiling.

      To your health,
      Evan Jerkunica

  44. Libby Potts says:

    I have had digestive problems my entire life. Runs in the family. I have been taking the product for a little over a week. 1st week could tell my body was getting rid of all the toxins and poisons. By day 6 I have been having reg. Bm’s and I am gaining energy every day. No more omeprazole problems. No heartburn or acid reflux at night. Thank you for a no nonsense resolution.

  45. evan says:

    Hi Dan,

    It’s important to ask your doctors if that is okay to take.

    To your health,
    Evan Jerkunica

  46. John Rolli says:

    What form is you B9 Folate? folic acid, methyl folate? its a deal breaker and you don’t specify. :(

    • evan says:

      Hey John,

      With regards to B9, this product has:

      • 800 mcg of DFE (aka methy folate aka 5-methyl-THF )
      • 480 mcg of Folic Acid

      There is a nutrition facts image up top. You can see it here:

      full ingredients for Synbiotic 365

      To your health,

      Evan Jerkunica

  47. Jennifer says:

    Do I need to continue taking Super B complex if I am taking Synbiotic 365?

  48. Kathleen Cronin says:

    Hello,

    Is this a capsule or pill? Is this live bacteria? My understanding of efficacy is that the bacteria must be live.

    Thank you,
    Kathleen C.

    • evan says:

      Hi Kathleen,

      Synbiotic is a capsule that contains live probiotics.

      The probiotics are freeze dried in a very careful way to make them hibernate or go dormant…but they are still alive.

      Once the probiotics get into your intestines, they wake up and become active again. The heat and moisture of your intestines wakes up the probiotics again and then they go to work.

      To your health,
      Evan Jerkunica

  49. Joe says:

    Is there supposed to be Chicory root in Synbiotic 365 or is that separate?

    • evan says:

      Hi Joe,

      Yes, chicory root is in Synbiotic 365.

      Chicory root is s a prebiotic that contains inulin. Inulin helps your digestion by:

      • nourishing your probiotics
      • improving digestion
      • decreasing constipation

      To your health,
      Evan Jerkunica

  50. Alena Jones says:

    I just ordered them and are now reading comments on the so if i take the 3 boxes for 3 months and then stop taking them then will my body react badly because i dont want to be on this pill forver

  51. Carol Anne Brown says:

    I was scheduled for a colonoscopy on May 1st, 2019. My 6 month bout with diarrhea warranted a look see. I decided to try Synbiotic365. It has been nearly three weeks. I have no more diarrhea and the Dr canceled the colonoscopy. Works for me!! Thank you to United Naturals.

  52. Dee Rook says:

    Just received my synbiotic 365, my question is I take royal jelly, a daily vitamin, garlic, and fish oil daily, are these ok to take along with symbiotic 365 or which ones should I not take?

    • evan says:

      Hi Dee,

      I would speak with a doctor to be sure. Only thing that sounds like it could potentially not be great is, you want to check how much B vitamin is in your vitamin supplement, so you don’t take too many B vitamins.

      To your health,
      Evan Jerkunica

  53. Brenda Smith says:

    hello i am considering purchasing a 3 month supply to start off, but I am concerned about the chicory root, I read on a google search that it can cause stomach upset and other gastro related symptoms, what are the benefits of including chicory root if it is questionable? at least to me.

    • evan says:

      Hi Brenda,

      Chicory root is a prebiotic. It is like fertilizer for the probiotics you take. So it amplifies the effect of taking probiotics.

      Chicory root also helps relieve constipation and improves digestion.

      I wouldn’t expect the amount in this probiotic to cause side effects. It’s a pretty small dose of prebiotics.

      To your health,
      Evan Jerkunica

  54. RaKay Sanchez says:

    how many come in a box/ package

    • evan says:

      Hi RaKay,

      There are 30 in each box.

      Each capsule comes in a blister pack – so they are quite fresh.

      To your health,
      Evan Jerkunica

  55. Cynthia Wallace says:

    This product’s formula looks great. I am hesitant only because the company that manufactures it is relatively new and does not have a track record in the supplement field. How do I know for sure that this product actually contains what it says it does?

    • evan says:

      Hi Cynthia,

      The only way to know for sure would be to do a very expensive chemical analysis on the product.

      At the end of the day, if a product does what you want it to do, it’s a good product. If it doesn’t, it’s a bad product.

      And just because a company is old and trusted, doesn’t mean it can’t be corrupted.

      Likewise, I new company can be better than an old company because it has newer, more effective ideas.

      But ultimately, if the product makes you healthier, that’s what matters. Otherwise I’d return it.

      To your health,
      Evan Jerkunica

  56. Mary Ulsh says:

    Dr. Vincent Pedre, you have United Naturals make the product. Are you sure the product stays the way you made it through United Naturals? I ask this because Brian Scott Peskin had a very oustanding product that he made an agreement to produce it, but in time the product was not what had been agreed by Mr. Peskin and the company that agreed to produce it according to his formula. I know as I tried it and I am still using the formula. Brian Scott Peskin had to get another company to produce it. All that were taking his product called him because we could see by using the product something was not happening. You are a doctor Mr. Peskin is a scientist and you do not have time to produce your product so you use a company to make it. I understand but in buying a product I need to know if there is ever change. Sincerely, Mary Ulsh

    • evan says:

      Hi Mary,

      I can’t speak for Dr. Vincent Pedre, but I believe that he is in contact with United Naturals most weeks.

      I know they have even made refinements to existing products over time…so they must work closely together.

      I know they are continuing to develop new products together…so that makes me believe that Dr. Pedre is happy with the partnership.

      To your health,
      Evan Jerkunica

  57. Mary Ulsh says:

    I have been using Synbiotic 365 and I like it very much. Of my order I give a box to my daughter in-law. She really needs it but I think she should take more. My precious daughter in-law is very tired and works nine hours a day. The company she works for wanted her to sign a contract that she would not retire or quit. She is very much honored by the company she works for. You said that taking more than one capsule would be fine but I need to know how it could be done before I talk to her. I read how United Naturals and Dr. Pedre got together. That makes me very comfortable. There one vitamin B not in the formula and that is B4. It is a very important vitamin. I feel every person should use Synbiotic 365 as it will help EVERY ONE. Sincerely, Mary Ulsh

    • evan says:

      Hi Mary,

      Wow – that must be great to have that sort of job security, what an honor!

      As long as she doesn’t have any health problems or organ problems, it’s probably okay to maybe take a 2nd pill. But, she should tread very carefully. If problems begin to develop, it would be wise to cut the dose back down.

      Taking too much of a probiotic can be worse than taking none at all: https://probiotics.org/side-effects-of-probiotics/

      To your health (and your daughter-in-law’s health),
      Evan Jerkunica

  58. Bernie says:

    I love this product! I have been taking it for 3 solid weeks and my acid re flux is gone. I don’t have any more bloating, I’ve lost weight and my gut feels better than it has in five years. That daily nagging discomfort in my gut and bloating no longer are part of my life. I also seem to have more energy. I have not experienced any side effects what so ever. I bought a 90 day supply
    but I intend to order more if everything continue to go well.

  59. James says:

    I have been taken it in the morning with a cup of coffee is this ok

    • evan says:

      Hi James,

      That’s probably fine. But if the coffee is very hot, you could “burn” the probiotics and decrease their effectiveness.

      But, I think it’s better to take it on a empty stomach with a glass of water.

      To your health,
      Evan Jerkunica

  60. Ela says:

    I noticed a lot of people asks very important questions about the product safety to kids or mixed with other vitamins or medicines to other regular people..Can Dr Pedre answer all?? He tested,experimented and made the product…WHERE ARE YOU HIDING MR DR PEDRE..PEOPLE HAVE CONCERNES..NEED YOU TO ANSWER IMMEDIATELY!!!!!!

    • evan says:

      Hi Ela,

      A good doctor, like Dr. Pedre, won’t give universal medical advice to everyone over the internet. Saying things like “eat vegetables” is fine of course, but it gets more complicated when drugs are involved.

      The reason is that you could have a very specific condition that means that you can’t mix a specific drug and a specific supplement.

      That’s why he can’t say something like “yes it’s 100% safe in all cases to take drug X with supplement Y”. Saying things like that could get people killed or make people sick.

      That’s why you should check with a doctor when you’re mixing drugs with supplements. Or, maybe you should be careful about mixing too many supplements together if you have certain organ failures or weakness.

      To your health,
      Evan Jerkunica

  61. Patricia says:

    I bought the 6 Box deal of the symbiotic 365, along with a single bottle of the Enzyme 365. I’ve been taking the one for 17 days, and the Results are amazing!! I have had stomach issues for many years, but since taking the Symbiotic 365 the Severe Cramping is just about gone!!! My Question is, do I Need to continue to take the Enzyme along with the Symbiotic, or will it work just by itself??… I Also took them both to my Dr, and he said they were ok to take, being they are water soluble…

    • evan says:

      Hi Patricia,

      I would take the probiotics on an empty stomach, and I would take the enzymes towards the middle of a meal. Taking enzymes on an empty stomach might possibly cause problems in the long term according to some research I’ve read.

      To your health,
      Evan Jerkunica

  62. Bobbie Graham says:

    I ordered Synbiotic 365 and Enzyme 365. Should these be taken together? Does Enzyme 365 amplify the effects of Synbiotic 365? The advertisement for it was not clear in this respect.
    I am not going to begin the dosages until I receive your answer. Thank you.

    • evan says:

      Hi Bobbie,

      I take digestive enzymes during a meal.

      I would take Synbiotic 365, first thing in the morning on an empty stomach.

      Of course if a health professional or doctor tells you otherwise, you should do what they say.

      To your health,
      Evan Jerkunica

  63. will victory says:

    Just received my blister pack and after reading here can’t wait to get going.
    If you know what I mean.
    Will be super happy if it’ll help with all digestive concerns I experience.
    Fingers crossed bigtime!

  64. Patricia Sullivan says:

    should this product be taken if on long term doxycycline treatment (six months) or should I wait until antibiotic treatment is finished?

    • evan says:

      Hi Patricia,

      In this article here, we discuss the researching showing people likely benefit by taking probiotics during antibiotic treatment.

      But, to be sure, you need to ask your doctor if that is the correct course of action in your specific case.

      To your health,
      Evan Jerkunica

  65. Nicole says:

    I’ve just ordered the Symbiotic 365 and am beginning my second blister-pack card. I am happy so far. Why are people also taking the Enzyme 365? Isn’t the original Symbiotic 365 enough?

    • evan says:

      Hi Nicole,

      There are some things that enzymes can do that probiotics can’t do.

      For example, B12 vitamin, which can be found in red meat, cannot be digested without digestive enzymes. Probiotics would not directly help in digesting B12 from meat.

      And the enzymes in Enzyme 365 also help digest fats, proteins and carbohydrates more effectively. Enzyme 365 would be useful if you’re deficient in pancreatic enzymes.

      So that’s why it could be useful to take both Enzyme 365 AND Synbiotic 365.

      To your health,
      Evan Jerkunica

  66. Odelja Servo says:

    I have taken 5 tablets so far and cant see any improvement yet. I have constipation until I take Sendocot and then my stomack totally clears an then nothing until the next bout and so on my doctor suggested sendacot but I cant seem to get the right dose. I am hoping that 365 will get me back on track.

  67. Linda says:

    I have read many of the reviews but I have not found one that addresses someone who is underweight…Will this make me lose weight? Most people taking this has mentioned losing weight on this

  68. Kevin M. says:

    Evan-

    Thanks for the insight and the review— a lot of products out there to choose from so appreciate your effort in educating consumers. Is it ok to continue consuming Kombucha while taking Synbiotic 365 or is it overkill?

  69. Benjamin Smith says:

    Hello, I work out 5 days a week and also have MS and take Copaxone three days a week for MS. I also take a baby aspirin, Simvastatin (Lower Cholesterol) and Multi Vitamins. Are those medications OK to take with Synbiotic 365. Thanks, Ben

  70. bre says:

    is this safe for breastfeeding moms

    • evan says:

      Hi Bre,

      There have been loads of probiotic research studies with moms who are breastfeeding. That being said, Synbiotic 365 was not specifically used in those studies. But Synbiotic 365 is probably fine.

      As always, you should check with your doctor when you start taking a new supplement, just to be sure.

      To your health,
      Evan Jerkunica

  71. Kathryn Chambers says:

    How long before a meal can this be taken? I fast intermittently(2 days a week) and on those days I don’t eat anything until the evening meal. How can I incorporate Symbiotic 365 into this regimen since I don’t eat at all until late in the day. Thank you in advance for an answer

    • evan says:

      Hi Kathryn,

      The key is to take it on an empty stomach. First thing in the morning is typically when the stomach is the most empty.

      But if you fast until dinner, then you could take it around then on a very empty stomach.

      Synbiotic 365 contains B vitamins, which can increase energy and wakefulness. So, I would not take Synbiotic 365 within 3 hours of sleeping. That’s pretty consistent with Dr. Ben Lynch’s recommendation to not eat after 730pm, assuming a 1030pm bedtime.

      To your health,
      Evan Jerkunica

  72. gabby says:

    Hi, is it okay for a kid to take these? I want to make sure there aren’t any side effects.

  73. Judith Nowak says:

    I suffered with IBS for 12 years. I took other probiotics only to throw them away since they did not work. The Dr. told me there was nothing really that could be done about IBS. I saw the advertisement and tried Synbiotic 365 and it was a miracle for me. I have been free of IBS for over 3 months and I will never be without this supplement in my life.. Thank you Dr. Pedre I appreciate you and your staff…

  74. Daewon Kwon says:

    My wife always had digest problem and we tried all kinds of methods without success. I bought this for my wife but did not have much expectation that it would help her digestive problem. Wow… I was totally wrong. This works really well. She has been taking over the last two weeks and she is so happy. This is totally different probiotics product than others.

  75. April says:

    I took this for 6 weeks and lost 15 lbs.! I had so much energy I couldnt believe it! I highly recommend it! I will be ordering more!

  76. Polly Fortune-Garceau says:

    I recently received my order and amm wondering if it will hurt to continue taking my B-12 and B Complex that I have been taking. Can I get too much??

    • evan says:

      Hi Polly,

      I read up on this because it was my concern as well. I wasn’t able to find any serious side effects. The best I could find was that if someone has kidney problems, this can be more of an issue — but the website where I found that has since taken down that page.

      So I would say that there’s a good chance it’s fine, but you should always check with your doctor to be sure.

      To your health,
      Evan Jerkunica

  77. K G says:

    My wife has had really bad smelling flatulence over the past 5 years, and many nights I had to sleep in another bedroom it was so bad. She tried various probiotics with no significant benefit. Then she purchased you Synbiotic 365 and now … I am sooo happy! She still does some flatulence but the foul smell has all but gone. No more candles, fans and separate bedrooms. I am very happy for you to use my review except I don’t want my name published due to embarrassment for my wife.

    • evan says:

      Hi K G,

      I edited your name for extra privacy :)

      Thank you for taking the time to share yours and your wife’s experience.

      To your health,
      Evan Jerkunica

  78. Heidi L says:

    I have been taking Synbiotic 365 for 6 days now and have noticed remarkable relief from cramping and bloating. Energy has increased also. I seem to be losing some weight also which is great because I wanted to drop 10 pounds. My question is will there continue to be weight loss or will it stabilize at some point since I don’t want to lose more than 10-12 pounds. I am i pressed with your product. I had tried other probiotics, but found them ineffectual. I also forget to take them on an empty stomach and end up taking them mid day or later and I think it has been ok (??)

    • evan says:

      Hi Heldi,

      That’s great!

      I don’t think the weight loss would continue past an unhealthy point because of this product. In 9.5 years since startng Probiotics.org, I haven’t heard of anyone saying that happened to them, or any reports of that happening in the media.

      But of course keep an eye on it, and seek medical attention if something goes wrong.

      To your health,
      Evan Jerkunica

  79. Jayne says:

    Is there any possibility of kidney damage with Synbiotic 356? I’ve taken it for a couple of months and my renal enzymes have gone up a little, but that has happened before I started taking it with a BP med I took. Just wanted to make sure since this is the best product I’ve EVER found for irritable bowel. My doctor is no help.

    • evan says:

      Hi Jayne,

      I’d say if your doctor doesn’t see any ingredients harming your kidneys then it should be fine. But please let me know if you find new information.

      I’ve Google’d around and I wasn’t able to find anything negative with probiotics or B vitamins related to kidney issues. So it doesn’t sound like a common problem, but you have to check with your doctor.

      To your health,
      Evan Jerkunica

  80. Melinda Bolinski says:

    I have only been taking symbiotic 365 for less than a week, already no more hives, less belching, lost 3 pounds, sleeping good. So far I am very happy.

  81. Janette Winters says:

    Hello, My boyfriend and I have been taking Synbiotic 365 now for 9 days now. Just curious, is it okay to have a cup of coffee afterwards? I usually wait about 30 minutes or should I wait longer? I just want to be certain I’m not degrading the beneficial ingredients. How long should one wait before eating or drinking. Thank you.

    • evan says:

      Hi Janette,

      It’s hard to say exactly how long is enough. But I wouldn’t take it together with hot coffee.

      But 30 minutes should be enough – especially if you take the capsule with a nice glass of water.

      My gut feels best when I drink coffee after a full breakfast. The food seems to protect from the harshness of the coffee.

      So ideally (for me) it would be:

      1. water + capsule
      2. solid breakfast
      3. coffee after breakfast
  82. Bernadette Wright says:

    This is the best product I have taken. I was having trouble having pains in my stomach after eating certain foods. My gut was miserable and I felt miserable. I began taking Synbiotic 365 and immediately began feeling better. My acid reflux disappeared and my gut felt wonderful; no more pains and discomfort. I would recommend it to anyone who is having the problem I had.

  83. Irene M. says:

    I was watching the video and at the very end when he said to press the “next“ Button, it would not work. I pushed and pushed and then it disconnected me from the site. You offered a discount on three and six months packages. How can I still get this discount.

  84. Joan l England says:

    I really liked this but I need more where do I get it?

  85. Kara says:

    Can the capsule be opened and the powder be dissolved in water?

    • evan says:

      Hi Kara,

      Yes that’s fine. Make sure the water is room temperature – hot water will boil the bacteria alive

      To your health,
      Evan Jerkunica

  86. Janice says:

    I started taking your product recently & after taking one box, I was looking to purchase more. Your product is not a sham like so many others. No I haven’t lost any weight yet, but I do feel better & I am so glad that I discovered your site. Is there a way to sign up to get this automatically shipped to me every month? Please send me an email & let me know how to get on an automatic monthly or two month shipment? Your product don’t smell funny or upset my stomach like many others. I was running out. Originally I was afraid to purchase more than two months supply. Thank you for selling this product.

  87. Linda says:

    Is this product gluten free?

    • evan says:

      Hi Linda,

      Yes it is. I’ve heard that people with celiacs were able to take the product without problems.

      To your health,
      Evan Jerkunica

  88. Brenda says:

    Hi, I just received my product today and can’t wait to start tomorrow. I have a lot of bloating and gas. Can’t wait to see how it will works. I have changed my whole diet as well

  89. James M Kottinger says:

    Why would you recommend taking 3 in 1 symbiotic 365, before breakfast? Wouldn’t it be better before going to bed as the body repairs itself?

    • evan says:

      Hi James,

      The idea is that when you take it before breakfast, you have the least amount of food in your intestines – so everything in Synbiotic 365 is more likely to be absorbed.

      Also – Synbiotic 365 has B vitamins which can make you a bit too energetic before bed. They aren’t as strong as caffeine, but for that reason I would not take these ~2 hours before bed.

      To your health,
      Evan Jerkunica

  90. Deb says:

    Hi,
    In your above response to Jordan, the 25 year old, I believe you misunderstood her question and I would actually like to know your take on it. She wanted to know if after an initial period of taking 1 pill everyday, would it be effective still if she then changed to taking 1 pill every other day (a change from 7 pills a week to 3 or 4 per week). What is your understanding?

    • evan says:

      Hi Deb,

      You’re right – I did misread it.

      There’s no way to know for sure. That person could try taking it 3-4 times a week, and see how it works.

      To your health,
      Evan Jerkunica

  91. Mary says:

    I am thinking about ordering the 365 product but want to know if the effectiveness is decreased in shipment during the warm summer months? Are these shipped in any kind of a cooler pack to prevent degeneration? Are they shipped within the states by US mail, FedEx or UPS? Thank you

    • evan says:

      Hi Mary,

      That’s a very good question. Probiotics, even for freeze dried probiotics like in Synbiotic 365, don’t want to be too hot or they can die before they reach your intestines. And the probiotics can get hot during shipping.

      Synbiotic 365 has already thought of that though. Here’s 3 ways they make sure you get potent probiotics even on a hot day:

      1. Some strains are very heat resistant
        • saccharomyces boulardii
        • OPTI-BIOME Bacilius subtilis
      2. For other non-heat resistant strains, they put 1.85x to 2x more probiotics than claimed – it may say 20 billion CFU on the label, but actually there are 35-40 billion before they are manufactured
      3. They order small batches – so inventory doesn’t sit for years…becoming weaker over time

      So that means that even if some probiotics get too hot during shipment, there is plenty extra to make up for it.

      That’s a good question Mary!

      To your health,
      Evan Jerkunica

  92. Eva Grant says:

    Hi! Can Gut Connect 365 be taken along with Symbiotic 365 OR should a detoxifying fasting process take place FIRST to mend leaky gut before beginning Symbiotic 365?

    Thanks.

    • evan says:

      Hi Eva,

      I think it’s fine to take them together. But to be sure it’s right for you, you should ask your doctor in case you have any health conditions that could complicate things.

      When it comes to detoxifying fasting, I am not very familiar with that. I’m sorry I can’t answer your question on that.

      To your health,
      Evan jerkunica

  93. Allison says:

    I am really interested in this product, however, I didn’t hear anything mentioned on it’s compatibility with those of us with thyroid issues. Please address this issue so I can evaluate whether this product is beneficial for me. Thank you.

  94. Donald Vining says:

    This product has worked miracles on my stomach. After a week I stopped taking all ulcer and gerd remedies. I also find I am sleeping much better and I am looking forward to seeing what else this product cures. Good gut health is very important to overall well being! I HIGHLY RECOMMEND IT.

  95. Deborah Perry says:

    I want to start this product I have read all your information, but I am allergic to fish. Are there any fish or fish oil ingredients in this product. Ready to purchase if free of thirds.

    • evan says:

      Hi Deborah,

      I spoke with United Naturals and here’s what they said:

      Synbiotic 365 is free of fish oil and fish.

      To your health,
      Evan Jerkunica

  96. Benjamin Morris says:

    I suffer from Ulcerative colitis looking for a probiotic to help improve my gut. Colonoscopy revealed dysplasia. Not going to be able to reverse this put hopefully prolong surgery. Would you recommend Synbiotic 365 to help??

  97. Shelby Miller says:

    My husband and I both started using, the probiotic, Symbiotic 365, about a year ago. We both were suffering with gut problems and had tried several items. We have been very impressed with the change, in our life. This is an excellent probiotic. I just ordered another supply of Symbiotic 365. Thanks!

  98. Dana says:

    Good evening Evan! What month/year did you write this review please? Thank you in advance for your reply.

    • evan says:

      Hi Dana,

      I originally wrote it November, 2018.

      But, I keep adding and updating it as new questions are asked, or the formula is changed.

      To your health,
      Evan Jerkunica

  99. debra says:

    I purchase your product a year ago and am just getting around to taking it. Will it still have its strength and effectiveness?

    • evan says:

      Hi Debra,

      I spoke with United Naturals, and they said:

      the product has a 2 year shelf life.

      So it should be fine as long as it was stored well.

      Best,
      Evan Jerkunica

  100. Deb says:

    I have been taking Synbiotic 365 for 3 months now and have lost 18 lbs and feel absolutely wonderful. I no longer have bloating and have more energy! I highly recommend this!

  101. Tracie Rice says:

    Is there anywhere in London UK to buy this product and if not, do you ship?

    • evan says:

      Hi Tracie,

      I don’t believe they directly ship to England. But, there are services where you can have the product shipped to a USA address, and they’ll forward it on to your England address.

      Best,
      Evan Jerkunica

  102. joyce aurich says:

    Finally, a Product that has my GI tract back on track. I’ve had trouble for at least 2 decades and now I’m normal again…

  103. Kathryn says:

    I am using a multi vitamin with Biotin, (5,000 mcg), Antioxidants, (Vit C & E), Vit B6 (4.3mg), & Vit B12 ( 9 mcg), per serving. Primarily for hair, skin & nails. Can I continue taking these while using your product?

    • evan says:

      Hi Kathryn,

      Ultimately you would need to check with your doctor. I haven’t heard of anything bad happening from taking more than recommended B vitamins, but you could have an underlying condition that your doctor would be able to advise you about correctly and safely.

      To your health,
      Evan Jerkunica

  104. Erwina Brillantes says:

    Will this help someone with fatty liver?

    • evan says:

      Hi Erwina,

      I would speak with your doctor on what to do. There is a slight chance though that due to the weight loss properties of the L gasseri strain that is in this product, it could help reduce weight, and that might possibly help with NAFLD. You would need to speak with a doctor thought to be sure – there may be other considerations so please check with yoru doctor.

      Best,
      Evan Jerkunica

  105. Sheila says:

    Where do i re-order?

  106. Lisa says:

    I have been taking for 6 days. To day was the best I have felt in a long time.

  107. Charlene Palmer says:

    I have had stomach issues for years and the symptoms kept getting worse this past year. Everything I ingested caused pain, bloating, and diarrhea. I started GutConnect 365 Oct.15 and I have not had any stomach issues since I have taken it. I can eat salad again without pain! I love this product! It has changed my life! Thank you!

Leave a Reply

Your email address will not be published. Required fields are marked *

Free Probiotics Guide

Learn to feel better with the Probiotics.org newsletter (and get a free probiotics guide).

Probiotics.org Tools

Our Most Popular Articles

Free Probiotics Buying Guide

Want to buy the best probiotics for you and your health? Then you should click here to download the Probiotics Buying Guide.

Featured Product Reviews:

read Synbiotic 365 review.