Review of Synbiotic 365 from United Naturals

Review Rating:

Best for: Digestive Health

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Transparency disclosure: for each person who buys this product by clicking a link on this page, receives a small percentage of the sale. I would strongly recommend this product without compensation, but I want you to know all the potential motivations for writing this review. Transparency rules!

Review Summary

United Naturals is a digestive health company started in 2017 by a Canadian founder. Their first product is Synbiotic 365 which contains a novel blend of probiotics, prebiotics and B vitamins.

Based on my 9 years running, this is one the most carefully researched probiotic blends I’ve ever found. It’s well suited to digestive health, plus it supports vitamin B deficiencies that are common in people with digestive issues.

Synbiotic 365 is a very innovative “3-in-1” product for digestive health.

Video Review of Synbiotic 365

What Was The Inspiration For Creating Sybiotic 365?

I interviewed the Canadian founder of United Naturals about how he become interested in digestive health. He said that his initial interest in digestive health came from his girlfriend who was having life-destroying digestive issues.

He started looking into what might help her digestive health, and landed on probiotics. Laboratory testing also found that her vitamin B levels (B12 and B6 were most deficient) were quite depleted. And because she was having issues digesting vegetables containing prebiotics, her digestive health was further boosted by taking a prebiotic.

United Natural’s Formula Was Perfected By Dr. Vincent Pedre

Even though this combination of probiotics/prebiotics/B vitamins worked well for his girlfriend digestive issues, United Natural’s founder wanted to make sure it was the perfect digestive health formula. So he teamed up with Dr. Vincent Pedre out of New York to perfect the the Sybiotic 365 formula.

Dr. Vincent Pedre specializes in internal medicine and was educated at Cornell university. Dr. Vincent Pedre brought out his extensive medical knowledge and experience to create the optimum digestive health formula. This new formula reflects the latest probiotic and digestive research. And this product may be your best chance for better digestive health.

Ingredients in Synbiotic 365

In this part of the review we’re going to break down every single ingredient that this product has.

Probiotics in This Product

I’m very impressed with the large range of highly research probiotic strains in this product. I’ll go over the dosage and individual strains below.

30 Billion CFU Per Capsule

This United Naturals probiotic has 30 Billion CFU in each capsule. And if you’ve downloaded our probiotics buying guide, you know that that’s a great starting dose of probiotics.

This “Goldilocks CFU” is the highest dose I recommend to people buying their first probiotic…it’s a good dose that reduces the chance of side effects, yet it’s strong enough for most people to have symptomatic relief. And if someone wants a higher dose, they can take multiple capsules, spaced throughout the day.

Contains 14 Proven Probiotic Strains

This product has 14 different probiotic strains in it. Each one of these strains is extensively researched and have research supported digestive health benefits. Additionally, many of these probiotic strains also have immunity and anti-allergy health benefits.

  • Lactobacillus acidophilus La-14™
  • Bifidobacterium lactis Bl-04™
  • Lactobacillus paracasei Lpc-37™
  • Lactobacillus plantarum Lp-115™
  • Streptococcus thermophilus St-21™
  • Lactobacillus casei Lc-11™
  • Lactobacillus reuteri
  • Lactobacillus salivarius Ls-33™
  • Lactobacillus rhamnosus Lr-32™
  • Lactobacillus gasseri Lg-36™
  • Lactobacillus fermentum
  • Bifidobacterium bifidum Bb-06™
  • Bifidobacterium longum Bl-05™
  • Saccharomyces boulardii


This product contains 350 mg of chicory root inulin. This is a high quality plant derived prebiotic and is very well researched.

B Vitamins

An extremely common B vitamin deficiency for people who have digestive issues is B12 deficiency. Because of that, Sybiotics 365 has 1000% of the daily value of this nutrient.

For the following B vitamins, this product contains 200% of the daily value:

  • B1 – 200% DV
  • B2 – 200% DV
  • B3 – 200% DV
  • B5 – 200% DV
  • B6 – 200% DV
  • B7 – 200% DV
  • B9 – 200% DV

People can have all sorts of health problems from thinning hair, all the way to extreme fatigue by being deficient in B vitamins. So I like that this product supports those aspects of our health as well.

Other ingredients

The inactive ingredients are hypromellose and rice hull concentrate.

I know for a fact rice hull concentrate is safe unless you have a rice allergy which is quite rare.

I looked into hypromellose and I couldn’t find any credible evidence that there is anything unsafe about it. There were some crazy hippie blogs saying it was bad, but those blogs did not show any evidence or sources for why it is bad or unhealthy. I took this product and didn’t notice any effects myself.

Synbiotic 365 Allergen Information

United Naturals made this probiotic to be consumable for people with food allergies and sensitives. Please see the allergen information below.

Gluten Free Probiotic – Taken By People With Celiac Disease

The founder told me that this product is gluten free, and people with Celiac’s disease have not had negative reactions to the product. I have a very good friend with Celiac’s disease, so I’m glad he can take this product without fear.

Dairy Free Probiotic – Okay for Dairy Intolerant People

This product contains no diary or lactose. The manufacturer of this product says that some dairy is used in culturing the probiotic strains. But only extremely trace levels of dairy should be present. The founder says that there have been no complaints or issues for people who are dairy free.

No Soy, Eggs or Nuts in this product

There aren’t any eggs, nuts or soy in this product. There is also no cross-contamination of these allergens.

Synbiotic 365 is GMO Free

None of the ingredients in this supplement contain genetically modified organisms (GMO’s).

What Is The Synbiotic 365 Starting Dosage?

The starting dosage for Sybiotic 365 is just 1 capsule per day. I like to take the capsule on an empty stomach with 8oz of water.

Do They Offer A Money Back Guarantee?

Yes! I really respect companies that give a money back guarantee. That shows that the company believes 100% in their product. And for you, there is no risk in trying this product.

Are There Any Sybiotic 365 Scams?

The internet is a big place, and there is always a chance people are counterfeiting the product or running another type of scam. To avoid any chance of scams, buy directly from the company at

Any Product Complaints?

I didn’t have any issues with this product. The ingredients are clean and the research behind them looks sound. No complaints from me.

Does United Naturals Have Good Customer Support?

I called their company after hours, left a message and got a call back early the next day. I think that’s very responsive and reasonable.

Where Can You Purchase Synbiotics 365?

The best place to purchase this product is direct from the manufacturer. You can buy just 1 box, or, you can get a large discount by ordering ordering multiple boxes.

Review Rating:

Best for: Digestive Health

Click here to buy direct (best price)

No Risk – 30 day money back guarantee

8 comments on “Synbiotic 365 Review – Probiotic By United Naturals” - Click here to write your comment

  1. Orrin Doxer says:

    I just purchased a large supply of Synbiotic 365 and have taken 1 per day for the past 5 days. I stopped Prilosec and all other antacids. I have a long history of ulcers, gerd, stress, anxiety and overeating. Basically that’s all in the past. I’m 76 and in good health. I exercise regularly, eat healthy but still have night time munchies. I’m feeling very positive about using Synbiotic. Is there any benefit to increasing my dosage by adding one more pill per day?

    • evan says:

      Hi Orrin,

      There is a greater risk of probiotic side effects by taking more than 1 pill per day. But, if it works for you without side effects, I say full steam ahead.

      Evan Jerkunica

  2. DiAnne Slater says:

    Just ordered Dr. Vincent Pedre’s Symbiotic 365. Many reviews about this probiotics were mostly neutral. Did see one ingredient, cyanide (shortened term) causing concern from one reviewer. After reading several reviews, I like yours best. Looks like @ 880 + views so far. I’m motivated to give Symbiotic 365 a fair trial for 90-Days. Time will tell. “I gut this!”

    • evan says:

      Hi DiAnne,

      I posted a picture of the ingredients…there is no cyanide lol.

      B12 is cyanocobalamin – not cyanide…
      B3 is niacinamide – also not cyanide…

      Reviewers need to have some scientific literacy – geeze.

      That’s like saying methylfolate is methamphetamine…when methylfolate is a great nutrient found in green leafy vegetables.

      Evan Jerkunica

  3. Julissa says:

    I just had a baby 3 months ago. I had c section, I already had problem on my stomach. But I’m worried that my problem came back it hurts on the left side thinking that is my instestines. My question is it save to drink while you are breast feeding. I used to drink Prilosec but since I’m breastfeeding I can’t take that type of meds. I just so much discomfort and I was thinking of trying this? It’s safe for kids as well?thanks

    • evan says:

      Hi Julissa,

      I would ask your doctor to make sure if it’s okay for you in your situation. I haven’t heard of any issues personally, but always check with your doctor.

      To your heath,
      Evan Jerkunica

  4. Rob Farkas says:

    how many doses are in a box?

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