Dr. Rose, M.D. (researcher)
Evan Jerkunica (writer)
Best for: Liver health
90 day money back guarantee
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Dr. Eward Rose, MD and I reviewed LiverMD because I’ve recently had some alarming blood tests showing that my liver might have issues.
Based on Dr. Rose’s research, we believe LiverMD has good research (21 research studies in all) supporting it’s potential to improve liver health.
LiverMD was created by Dr. David Kahana, who partnered with 1MD for their manufacturing expertise.
LiverMD supports liver health in 4 ways:
There is good evidence that each of these 4 things support liver health. So based on all the research, we rated LiverMD 5 out of 5 stars.
1MD also has a 100% money back, 90 day return policy, good customer service and a big discount for buying multiple bottles.
I’m very picky about what I put in my body – but I take LiverMD myself. The research suggests that it supports the hell out of my liver…so it’s easy to recommend this product :)
Your liver has over 6 different jobs. One of it’s most important jobs is to remove the following bad things from your blood:
But beyond just detoxifying your blood, your liver also:
While it only weighs about five pounds, your liver receives 25% of your heart’s output. This shows you how important the function of the liver is to the body.
Since Evan’s expertise is more in gut health and probiotics, we asked family physician Edward Rose, M.D. to review the components that make up LiverMD, a liver support product made by 1MD.
This product is a blend of 6 liver-supporting ingredients. There is good direct or indirect evidence that every one of these ingredients can improve liver health. We’ll go through all 6 ingredients below.
EVNolMax is a combination of tocopherols and tocotrienols, derivatives of Vitamin E derived from plants. Vitamin E is an antioxidant, meaning that it helps prevent damage to tissues and cells caused by various oxidants created by cells. The abnormal accumulation of oxidants can result in diseases including liver disease and even cancer.
A 2012 study by PatelA in surgical patients showed that vitamin E derivatives helped with healing and liver inflammation. Later, in 2013, MagosoB showed that tocotrienol supplements helped with healing from nonalcoholic fatty liver disease (NAFLD), a common disease of the liver thought to be related to diet, obesity, and high cholesterol. NAFLD is a risk factor for cirrhosis of the liver and liver failure.
Tocotrienols are very well-tolerated and seem to be the most effective antioxidants of the Vitamin E family. Both tocotrienols and tocopherols are found naturally in rice, wheat, barley, rye, and oats, as well as in many fruits. As such, they have been used for centuries as part of a healthy eating recipe for good health.
Squalenes are naturally-occurring organic compounds present in all plants and animals. The source of plant squalenes has generally come from vegetable oils, including amaranth seed, rice bran, wheat germ, and olives. Other sources of squalenes include genetically-modified yeast and shark liver. They are an important part of the age-old healthy eating diet.
Squalene is a building block for the production of endogenous steroids, including cholesterol. Curiously, taking in excess plant squalenes does not cause a person’s cholesterol to go up. In fact, squalenes help the liver to regulate the production of cholesterol and to reduce blood fats and lipids.C
In a mouse model, squalene improved the function of the powerhouses of the liver, the mitochondria.D We were not able to find any published research on human trials of squalenes in liver disease, but you can read more about them in an excellent recent review article.E
There are over 200 sterols that have been described by scientists. Vegetable oils are rich sources of phytosterols, especially coconut, palm, peanut, olive, and corn oils.F Plant sterols have long been known to reduce LDL cholesterol, and the FDA has even approved packaging language stating so. Whether or not squalenes result in fewer cardiac deaths or strokes is not known, but it makes sense.
We were not able to find human clinical trials of the effects of phytosterols on liver health, but it is known that sterols help in the production of the bile salts that people need for the digestion of fatty foods. This may improve the function of the liver.
Silybin is a derivative of the milk thistle plant and has been used for centuries for the treatment of liver diseases. This is likely the power hitter of this product. Milk thistle has known antioxidant properties that may be beneficial in conditions such as hepatitis, steatohepatitis, and cirrhosis. With all of its complex interactions in the body, the exact mechanism of action of silybin is not clear.
Clinical trials of silybin have shown conflicting results. A recent (2007) Cochrane Review of milk thistle evaluated 18 clinical trials consisting of 1,088 patients and found no consistent evidence of benefit.I Other less rigorous (and potentially more biased) reviewsJ,K arrived at the same conclusion. Silybin is safe and well-tolerated, but there are no human studies showing that it works in liver disease. Having said that, the liver thrives on antioxidants, enzymes that help it do its job of removing metabolic waste products (many of which are oxidants) from the blood stream.
N-acetyl cysteine (NAC) is a well-established medication used in the treatment of acetaminophen (Tylenol) overdose, thickened lung airway secretions seen in chronic obstructive pulmonary disease (COPD, or emphysema) and cystic fibrosis, prevention of liver disease (from acetaminophen overdose) and kidney disease (from intravenous contrast), and certain neuropsychiatric disorders. NAC increases tissue levels of glutathione, a strong antioxidant normally made by cells.
Clinical trials with NAC in liver disorders have been variable. One study found that NAC plus various antioxidants plus steroids in acute alcoholic hepatitis were no more effective than the steroids alone.L But a different research project showed that NAC enhanced the liver’s response to interferon therapy in chronic hepatitis C.M Many chronic human diseases are associated with oxidative stress. Clearly any product that helps produce antioxidants will be beneficial.
This is a newer agent for use as a medicine. It was first patented in 1960 and was first used as a medicine in 1968. It is on the World Health Association List of Essential Medicines, the most effective and safe medicines needed in a health system. It comes from the semiessential amino acid cysteine. A semiessential amino acid is normally made by the body, but people may need additional oral supplementation in times of metabolic stress (like in liver disease).
Alpha lipoic acid (ALA) has been well-studied in humans. It is an important ingredient in at least five enzyme systems, including the energy- and ATP-producing Krebs cycle. It is called a cofactor, a non-protein chemical compound that is needed by protein-based enzyme systems in order to function. ALA is produced normally in the human body, although supplementation has been shown to increase blood levels. It can also come from foods such as kidney, heart, liver, spinach, broccoli, and yeast extract, but there are very low levels in these dietary sources. For example, the early research study to analyze ALA required the processing of 10 tons of liver extract to get 30 g of ALA.N
Most commercially-available ALA is man-made. ALA is easily absorbed from the gut, so oral administration is a reliable method of administration. As a pharmaceutical agent, it is a newcomer on the scene in the fight against liver disease.
In research studies, it is not clear how well it works for liver diseases. One study showed that ALA provided protection against liver fibrosis and cirrhosis in a rat model of acute hepatic injury.O But another research study found that ALA did not help the mitochondrial disorder that happens with chronic liver disease.P
ALA is well-tolerated and safe. As a side note, ALA does help in burning mouth syndrome but does not help in malignancies, diabetes, or diabetic peripheral neuropathy.
Zinc is an essential trace element for humans and is needed for the function of over 300 enzymes and 1,000 RNA and DNA transcription factors. Deficiency of zinc is associated with a variety of human illnesses, and supplemental zinc has been recommended in cases of diarrheal illness, nutritional deficiency, and upper respiratory infections. It is involved in the systems that allow cells to talk to each other and helps control cell death and turnover.
Zinc glycinate is more available to the body after oral administration than zinc oxide.Q A recent reviewR reported that zinc was effective in reducing scarring and disease progression in alcoholic hepatitis as well as hepatitis C. Zinc also helps in the systemic reduction of oxidative stress and promotes repair processes.
One trial of zinc (complexed with carnitine) supplementation in 14 patients with hepatitis C related chronic liver disease used zinc supplements for 6 months.S During that period of time, liver tests improved significantly and inflammation decreased. It appears that zinc acted as an anti-inflammatory agent. However, hepatitis C viral loads were not affected.
Selenium is an essential nutrient required by all animals and most plants. It is used as a cofactor to reduce the amount of oxidants that we all have on board. As such, it is a potent antioxidant. For instance, it helps reduce the level of an enzyme that degrades DNA (avoiding cancer and aging) and mitochondria (improving energy). In high doses, however, selenium is toxic.
While research supports the role of selenium in the treatment of oxidative stress, clinical results of supplementation have been disappointing. A recent Cochrane Database ReviewT found no benefit of selenium (or four other dietary antioxidants) in chronic liver disease. But another study of an experimental model of non-alcoholic fatty liver disease showed that selenium reduced the scarring seen in cirrhosis.U It may helpful in certain thyroid problems as well.
Besides the vegetable capsule, these ingredients are used mainly for:
There isn’t much nutritional value for these ingredients, either positive or negative.
This product is free from common allergens. To be more specific LiverMD is:
A bottle of LiverMD lasts for 30 days. It has 60 pills, and you take 2 pills per day.
Each pill is shaped like a cylinder. It has a diameter of 1/4 of an inch (0.25″), and is 13/16 of an inch long (0.81″).
In the image you can see a red, round, 200mg Ibuprofen pill. The middle sized pill is a 500mg tylenol pill. And the yellow-ish capsule is the LiverMD pill. The LiverMD capsule is slightly larger than the 500mg Tylenol pill.
Yes – it can be. The powder tastes a sour/onion-y. It didn’t taste bad mixed into water. But because of the amino acids NAC (N-Acetyl Cysteine), you should only mix this in room temp or cold water.
The best place to purchase LiverMD is direct from the 1MD. This way you can take advantage of the 90 day money back guarantee that isn’t offered anywhere else.
LiverMD offers a 12% discount for buying 3 bottles, and a 20% discount for buying 6 bottles. So even if you just want to try it, you can take advantage of the discount by buying multiple bottles, and then returning any you don’t want.
1MD has the strongest customer return policy that I’ve seen. If you aren’t 100% happy, they will give all your money back. It’s easy to recommend products from a company like this!
Best for: Liver health
90 day money back guarantee
You know I’ve rated this product 5 stars, and I take LiverMD myself, but maybe you want to hear what other customers think: You can read other customer reviews over at 1MD’s product page.
Once you get to their page, just scroll down, and click on the “reviews” tab, and you can read customer reviews.
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