Dr. Rose, M.D. (researcher)

Evan Jerkunica (writer)

1MD’s LiverMD Review

Review Rating:

Best for: Liver health

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LiverMD Review Summary

Dr. Eward Rose, MD and I reviewed LiverMD because I’ve recently had some alarming blood tests showing that my liver might have issues.

Based on Dr. Rose’s research, we believe LiverMD has good research (21 research studies in all) supporting it’s potential to improve liver health.

LiverMD was created by Dr. David Kahana, who partnered with 1MD for their manufacturing expertise.

LiverMD supports liver health in 4 ways:

  1. antioxidants
  2. amino acids
  3. enzyme building blocks
  4. essential minerals

There is good evidence that each of these 4 things support liver health. So based on all the research, we rated LiverMD 5 out of 5 stars.

1MD also has a 100% money back, 90 day return policy, good customer service and a big discount for buying multiple bottles.

I’m very picky about what I put in my body – but I take LiverMD myself. The research suggests that it supports the hell out of my liver…so it’s easy to recommend this product :)

Why Does Liver Health Matter?

Your liver has over 6 different jobs. One of it’s most important jobs is to remove the following bad things from your blood:

  • detoxifies – removes toxins from your blood
  • excess vitamins
  • medical drugs
  • viral borne infections (eg. mononucleosis and hepatitis)
  • processes alcohol

But beyond just detoxifying your blood, your liver also:

  • helps recycle iron from red blood cells
  • helps balance blood sugar levels
  • produces bile to digest fats
  • helps with blood clotting
  • helps fight infection

While it only weighs about five pounds, your liver receives 25% of your heart’s output. This shows you how important the function of the liver is to the body.

Since Evan’s expertise is more in gut health and probiotics, we asked family physician Edward Rose, M.D. to review the components that make up LiverMD, a liver support product made by 1MD.

“Active” Ingredients

This product is a blend of 6 liver-supporting ingredients. There is good direct or indirect evidence that every one of these ingredients can improve liver health. We’ll go through all 6 ingredients below.

EVNolMax

EVNolMax is a combination of tocopherols and tocotrienols, derivatives of Vitamin E derived from plants. Vitamin E is an antioxidant, meaning that it helps prevent damage to tissues and cells caused by various oxidants created by cells. The abnormal accumulation of oxidants can result in diseases including liver disease and even cancer.

A 2012 study by PatelA in surgical patients showed that vitamin E derivatives helped with healing and liver inflammation. Later, in 2013, MagosoB showed that tocotrienol supplements helped with healing from nonalcoholic fatty liver disease (NAFLD), a common disease of the liver thought to be related to diet, obesity, and high cholesterol. NAFLD is a risk factor for cirrhosis of the liver and liver failure.

Tocotrienols are very well-tolerated and seem to be the most effective antioxidants of the Vitamin E family. Both tocotrienols and tocopherols are found naturally in rice, wheat, barley, rye, and oats, as well as in many fruits. As such, they have been used for centuries as part of a healthy eating recipe for good health.

Plant Squalenes

Squalenes are naturally-occurring organic compounds present in all plants and animals. The source of plant squalenes has generally come from vegetable oils, including amaranth seed, rice bran, wheat germ, and olives. Other sources of squalenes include genetically-modified yeast and shark liver. They are an important part of the age-old healthy eating diet.

Squalene is a building block for the production of endogenous steroids, including cholesterol. Curiously, taking in excess plant squalenes does not cause a person’s cholesterol to go up. In fact, squalenes help the liver to regulate the production of cholesterol and to reduce blood fats and lipids.C

In a mouse model, squalene improved the function of the powerhouses of the liver, the mitochondria.D We were not able to find any published research on human trials of squalenes in liver disease, but you can read more about them in an excellent recent review article.E

Phytosterols

There are over 200 sterols that have been described by scientists. Vegetable oils are rich sources of phytosterols, especially coconut, palm, peanut, olive, and corn oils.F Plant sterols have long been known to reduce LDL cholesterol, and the FDA has even approved packaging language stating so. Whether or not squalenes result in fewer cardiac deaths or strokes is not known, but it makes sense.

Phytosterols are absorbed quickly after oral administration and are very safe. Besides their impact on cholesterol, sterols may have anticancer effects as reported by various studies.G,H

We were not able to find human clinical trials of the effects of phytosterols on liver health, but it is known that sterols help in the production of the bile salts that people need for the digestion of fatty foods. This may improve the function of the liver.

Silybin

Silybin is a derivative of the milk thistle plant and has been used for centuries for the treatment of liver diseases. This is likely the power hitter of this product. Milk thistle has known antioxidant properties that may be beneficial in conditions such as hepatitis, steatohepatitis, and cirrhosis. With all of its complex interactions in the body, the exact mechanism of action of silybin is not clear.

Clinical trials of silybin have shown conflicting results. A recent (2007) Cochrane Review of milk thistle evaluated 18 clinical trials consisting of 1,088 patients and found no consistent evidence of benefit.I Other less rigorous (and potentially more biased) reviewsJ,K arrived at the same conclusion. Silybin is safe and well-tolerated, but there are no human studies showing that it works in liver disease. Having said that, the liver thrives on antioxidants, enzymes that help it do its job of removing metabolic waste products (many of which are oxidants) from the blood stream.

N-Acetyl Cysteine

N-acetyl cysteine (NAC) is a well-established medication used in the treatment of acetaminophen (Tylenol) overdose, thickened lung airway secretions seen in chronic obstructive pulmonary disease (COPD, or emphysema) and cystic fibrosis, prevention of liver disease (from acetaminophen overdose) and kidney disease (from intravenous contrast), and certain neuropsychiatric disorders. NAC increases tissue levels of glutathione, a strong antioxidant normally made by cells.

Clinical trials with NAC in liver disorders have been variable. One study found that NAC plus various antioxidants plus steroids in acute alcoholic hepatitis were no more effective than the steroids alone.L But a different research project showed that NAC enhanced the liver’s response to interferon therapy in chronic hepatitis C.M Many chronic human diseases are associated with oxidative stress. Clearly any product that helps produce antioxidants will be beneficial.

This is a newer agent for use as a medicine. It was first patented in 1960 and was first used as a medicine in 1968. It is on the World Health Association List of Essential Medicines, the most effective and safe medicines needed in a health system. It comes from the semiessential amino acid cysteine. A semiessential amino acid is normally made by the body, but people may need additional oral supplementation in times of metabolic stress (like in liver disease).

Alpha Lipoic Acid

Alpha lipoic acid (ALA) has been well-studied in humans. It is an important ingredient in at least five enzyme systems, including the energy- and ATP-producing Krebs cycle. It is called a cofactor, a non-protein chemical compound that is needed by protein-based enzyme systems in order to function. ALA is produced normally in the human body, although supplementation has been shown to increase blood levels. It can also come from foods such as kidney, heart, liver, spinach, broccoli, and yeast extract, but there are very low levels in these dietary sources. For example, the early research study to analyze ALA required the processing of 10 tons of liver extract to get 30 g of ALA.N

Most commercially-available ALA is man-made. ALA is easily absorbed from the gut, so oral administration is a reliable method of administration. As a pharmaceutical agent, it is a newcomer on the scene in the fight against liver disease.

In research studies, it is not clear how well it works for liver diseases. One study showed that ALA provided protection against liver fibrosis and cirrhosis in a rat model of acute hepatic injury.O But another research study found that ALA did not help the mitochondrial disorder that happens with chronic liver disease.P

ALA is well-tolerated and safe. As a side note, ALA does help in burning mouth syndrome but does not help in malignancies, diabetes, or diabetic peripheral neuropathy.

Zinc Glycinate

Zinc is an essential trace element for humans and is needed for the function of over 300 enzymes and 1,000 RNA and DNA transcription factors. Deficiency of zinc is associated with a variety of human illnesses, and supplemental zinc has been recommended in cases of diarrheal illness, nutritional deficiency, and upper respiratory infections. It is involved in the systems that allow cells to talk to each other and helps control cell death and turnover.

Zinc glycinate is more available to the body after oral administration than zinc oxide.Q A recent reviewR reported that zinc was effective in reducing scarring and disease progression in alcoholic hepatitis as well as hepatitis C. Zinc also helps in the systemic reduction of oxidative stress and promotes repair processes.

One trial of zinc (complexed with carnitine) supplementation in 14 patients with hepatitis C related chronic liver disease used zinc supplements for 6 months.S During that period of time, liver tests improved significantly and inflammation decreased. It appears that zinc acted as an anti-inflammatory agent. However, hepatitis C viral loads were not affected.

Selenium

Selenium is an essential nutrient required by all animals and most plants. It is used as a cofactor to reduce the amount of oxidants that we all have on board. As such, it is a potent antioxidant. For instance, it helps reduce the level of an enzyme that degrades DNA (avoiding cancer and aging) and mitochondria (improving energy). In high doses, however, selenium is toxic.

While research supports the role of selenium in the treatment of oxidative stress, clinical results of supplementation have been disappointing. A recent Cochrane Database ReviewT found no benefit of selenium (or four other dietary antioxidants) in chronic liver disease. But another study of an experimental model of non-alcoholic fatty liver disease showed that selenium reduced the scarring seen in cirrhosis.U It may helpful in certain thyroid problems as well.

Other Ingredients

  • Vegetable cellulose capsule
  • Vegetable oil powder
  • Rice flour
  • Silica

Besides the vegetable capsule, these ingredients are used mainly for:

  • making sure the right amount of each ingredient is in the capsule
  • making sure the the machine doesn’t get jammed up

There isn’t much nutritional value for these ingredients, either positive or negative.

Allergen Info

This product is free from common allergens. To be more specific LiverMD is:

  • Soy Free
  • Gluten Free
  • Dairy Free
  • Nut Free
  • Tree Nut Free
  • Egg Free

How Long Does a Bottle of LiverMD last?

A bottle of LiverMD lasts for 30 days. It has 60 pills, and you take 2 pills per day.

Pill Size

Each pill is shaped like a cylinder. It has a diameter of 1/4 of an inch (0.25″), and is 13/16 of an inch long (0.81″).

In the image you can see a red, round, 200mg Ibuprofen pill. The middle sized pill is a 500mg tylenol pill. And the yellow-ish capsule is the LiverMD pill. The LiverMD capsule is slightly larger than the 500mg Tylenol pill.

Is It Okay to Break Capsule Open?

Yes – it can be. The powder tastes a sour/onion-y. It didn’t taste bad mixed into water. But because of the amino acids NAC (N-Acetyl Cysteine), you should only mix this in room temp or cold water.

Where to Purchase

The best place to purchase LiverMD is direct from the 1MD. This way you can take advantage of the 90 day money back guarantee that isn’t offered anywhere else.

Big Discounts for Buying 3 or 6 Bottles

LiverMD offers a 12% discount for buying 3 bottles, and a 20% discount for buying 6 bottles. So even if you just want to try it, you can take advantage of the discount by buying multiple bottles, and then returning any you don’t want.

No Risk, 90 Day Return Policy

1MD has the strongest customer return policy that I’ve seen. If you aren’t 100% happy, they will give all your money back. It’s easy to recommend products from a company like this!

Review Rating:

Best for: Liver health

Click here to buy direct (best price)

90 day money back guarantee




What Do Other People Think of LiverMD?

You know I’ve rated this product 5 stars, and I take LiverMD myself, but maybe you want to hear what other customers think: You can read other customer reviews over at 1MD’s product page.

Once you get to their page, just scroll down, and click on the “reviews” tab, and you can read customer reviews.



Full Reference List

  1. Patel V, Rink C, Gordillo GM, et al. Oral Tocotrienols Are Transported to Human Tissues and Delay the Progression of the Model for End-Stage Liver Disease Score in Patients. J Nutr. 2012;142(3):513-519. doi:10.3945/jn.111.151902.
  2. Magosso E, Ansari MA, Gopalan Y, et al. Tocotrienols for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a randomised placebo-controlled clinical trial. Nutrition Journal 2013 12:1. 2013;12(1):166. doi:10.1186/1475-2891-12-166.
  3. Hien HTM, Ha NC, Le Thi Thom, Hong DD. Squalene promotes cholesterol homeostasis in macrophage and hepatocyte cells via activation of liver X receptor (LXR) α and β. Biotechnol Lett. 2017;39(8):1101-1107. doi:10.1007/s10529-017-2345-y.
  4. Ramírez-Torres A, Barceló-Batllori S, Fernández-Vizarra E, et al. Proteomics and gene expression analyses of mitochondria from squalene-treated apoE-deficient mice identify short-chain specific acyl-CoA dehydrogenase changes associated with fatty liver amelioration. Journal of Proteomics. 2012;75(9):2563-2575. doi:10.1016/j.jprot.2012.02.025.
  5. Gunes FE. Medical use of squalene as a natural antioxidant. Journal of Marmara University Institute of Health Sciences. 2013;3(4):220-228.
  6. Verleyen T, Forcades M, Verhé R, Dewettinck K, Huyghebaert A, De Greyt W. Analysis of free and esterified sterols in vegetable oils. Journal of the American Oil Chemists’ Society. 2002 Feb;79(2):117-22.
  7. Ramprasath VR, Awad AB. Role of Phytosterols in Cancer Prevention and Treatment. j aoac int. 2015;98(3):735-738. doi:10.5740/jaoacint.SGERamprasath.
  8. Woyengo TA, Ramprasath VR, Jones PJH. Anticancer effects of phytosterols. Eur J Clin Nutr. 2009;63(7):813-820. doi:10.1038/ejcn.2009.29.
  9. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Cochrane Hepato-Biliary Group, ed. Cochrane Database of Syst Rev. 2007;120(12):1370. doi:10.1002/14651858.CD003620.pub3.
  10. Dhiman RK, Chawla YK. Herbal Medicines for Liver Diseases. Dig Dis Sci. 2005;50(10):1807-1812. doi:10.1007/s10620-005-2942-9.
  11. Jacobs BP, Dennehy C, Ramirez G, Sapp J, Lawrence VA. Milk thistle for the treatment of liver disease: A systematic review and meta-analysis. The American Journal of Medicine. 2002;113(6):506-515. doi:10.1016/S0002-9343(02)01244-5.
  12. Stewart S, Prince M, Bassendine M, et al. A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis. Journal of Hepatology. 2007;47(2):277-283. doi:10.1016/j.jhep.2007.03.027.
  13. Beloqui O, Prieto J, Suarez M, et al. N-Acetyl Cysteine Enhances the Response to Interferon-α in Chronic Hepatitis C: A Pilot Study. Journal of Interferon Research. 1993;13(4):279-282. doi:10.1089/jir.1993.13.279.
  14. Reed LJ. A trail of research from lipoic acid to α-keto acid dehydrogenase complexes. Journal of Biological Chemistry. 2001 Oct 19;276(42):38329-36.
  15. Foo N-P, Lin S-H, Lee Y-H, Wu M-J, Wang Y-J. α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β. Toxicology. 2011;282(1-2):39-46. doi:10.1016/j.tox.2011.01.009.
  16. Pfeffer G, Majamaa K, Turnbull DM, Thorburn D, Chinnery PF. Treatment for mitochondrial disorders. – PubMed – NCBI. Cochrane Neuromuscular Group, ed. Cochrane Database of Syst Rev. 2012;45(6):1193. doi:10.1002/14651858.CD004426.pub3.
  17. Schlegel P, Windisch W. Bioavailability of zinc glycinate in comparison with zinc sulphate in the presence of dietary phytate in an animal model with Zn labelled rats. – PubMed – NCBI. J Anim Physiol Anim Nutr. 2006;90(5-6):216-222. doi:10.1111/j.1439-0396.2005.00583.x.
  18. Mohammad MK, Zhou Z, Cave M, Barve A, McClain CJ. Zinc and Liver Disease. Nutrition in Clinical Practice. 2012;27(1):8-20. doi:10.1177/0884533611433534.
  19. Himoto T, Hosomi N, Nakai S, et al. Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease. Scandinavian Journal of Gastroenterology. 2009;42(9):1078-1087. doi:10.1080/00365520701272409.
  20. Bjelakovic G, Gluud LL, Nikolova D, Bjelakovic M, Nagorni A, Gluud C. Meta‐analysis: antioxidant supplements for liver diseases – the Cochrane Hepato‐Biliary Group. Alimentary Pharmacology & Therapeutics. 2010;32(3):356-367. doi:10.1111/j.1365-2036.2010.04371.x.
  21. Clarke C, Baghdadi H, Howie AF, Mason JI, Walker SW, Beckett GJ. Selenium supplementation attenuates procollagen-1 and interleukin-8 production in fat-loaded human C3A hepatoblastoma cells treated with TGFβ1. Biochimica et Biophysica Acta (BBA) – General Subjects. 2010;1800(6):611-618. doi:10.1016/j.bbagen.2010.02.007.

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