Dr. Rose, M.D. (researcher)

Evan Jerkunica (writer)

1MD GutMD Review

Review Rating:

Best for: clinical-strength gut lining repair for leaky gut

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No Risk – 90 day money back guarantee

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Review Summary of Gut MD

GutMD is a blend that that is intended to fight leaky gut, like United Natural’s GutConnect 365. This blend uses a combination of plant prebiotics, HMO prebiotics, licorice root and L glutamine.

1MD’s GutMD is a blend of prebiotics that encourage the growth of healthy bacteria in the gut. These bacteria then improve the immune function of the gut and promote better overall health and repair. The human milk oligosaccharides are fascinating products with numerous far-reaching benefits, including improvement of the gut barrier function.

I’ve found this to be a solid all-around supplement for the relief of gut issues, including acid reflux and bloating. If you’ve had gallbladder surgery and are having digestion problems, you may find GutMD to be helpful. Many people report that they like to take GutMD along with their probiotic.

What Was Dr. David Kahana’s Inspiration For Creating Gut MD?

In his practice as a gastroenterologist, Dr. Kahana treats digestive issues, including the associated degradation of the intestinal lining. Recognizing the critical role of the gut lining in the immune system and nutrient absorption, he decided to formulate GutMD as a supplement to improve functionality of the intestinal lining, boost gut health and improve overall well-being.

GutMD Ingredient List


Glutamine is an amino acid that is abundant in the human body. It is manufactured primarily in the muscles of the body and is consumed mostly by the intestinal epithelium and the kidney. It is referred to as conditionally essential, meaning that the body can usually manufacture enough glutamine to meet its needs except in times of stress, at which point dietary supplementation becomes necessary. Dietary sources of glutamine include beef, chicken, fish, dairy, eggs, legumes, and a wide variety of other vegetables.

Physiologically, glutamine is involved in protein synthesis and lipid synthesis. It plays an important role in cellular energy production, nitrogen donation, and acid-base regulation. At a tissue level, it helps maintain the intestinal epithelial lining. It is safe in all age groups; adverse effects of supplemental glutamine have only been reported after parenteral administration.

A recent study by van ZantenA showed that oral administration of glutamine significantly decreased length of hospital stay and in-hospital mortality in critically ill patients, but they didn’t say why. Another fascinating study by ZuhlB showed that L-glutamine administration after intense exercise reduced the rise often seen in intestinal permeability (“runner’s trots” or “trotter’s runs”).

CARE4U (Human Milk Oligosaccharides)

Human milk oligosaccharides (HMOs) are complex sugars found in human breast milk. These compounds have been shown to have the following functions C:

  • Prebiotics, stimulating colonization by beneficial microbes
  • Nonspecific defense against pathogenic bacteria and viruses
  • Signaling molecules that interact with host cells
  • Immune system controllers and anti-inflammatories, controlling the gut-associated lymphoid tissue responses to ingested antigens
  • Nutrients for neurological development of infants

These compounds have been studied over the past few decades and are increasingly understood to be important nutrients for infants. They are not absorbed by infants, but directly feed an important strain of intestinal bacteria called Bifidobacterium longus subspecies infantis. This organism provides important protective functions for infants and may even contribute to improved brain developmentD.

In adults, the role of HMOs is being studied. One recent study of HMOs administered to 100 healthy adults showed a shift in gut bacteria towards a more healthy microbiomeE. These same findings were shown in another study by AdamsF. A doctoral thesis investigation by Wu showed that HMOs improved the barrier function of the intestines by increasing mucous production by intestinal cellsG. Human breast milk is a powerful antioxidant and anti-inflammatory in infants and likely provides similar benefits to adults through HMOsH.

Gutgard (Licorice Root)

Licorice is a perennial legume grown mostly in the Middle East and the United States. It is used as a flavoring and a sweetener, and has been used since ancient times by herbalists for treatment of GI disorders. It has antioxidant and anti-inflammatory properties, and some claim anti-tumor effects as well. One component of licorice, glycyrrhizin, has been removed for this preparation, presumably to reduce the potential side effects of hypertension and edema. Recent studies with licorice have explored it effects in neurocognitive disorders. A recent study by ChoI showed that three varieties of licorice were effective in reducing the neurocognitive decline seen in a mouse model of inflammation-induced cognitive dysfunction. Jung et alJ found that licorice root extracts helped reduce alcohol-related liver disease, also through its anti-oxidative and anti-inflammatory properties. YangK published a review of all of the purported pharmacologic effects of licorice. Licorice has been shown by several authors to interfere with several medications and to have estrogenic (anti-testosterone) effects.

Fibregum (Acacia Fiber)

Acacia is a soluble dietary fiber, meaning it is a complex polysaccharide that is primarily indigestible to both humans and animals. It has an excellent safety profile. Relevant to the current product, it is not degraded in the intestine, but is fermented in the colon by microorganisms. It is therefore a prebioticL. In fact, several articles refer to it as “bifidogenic”, as it supports the growth of Bifidobacteria in the gutM. It is a known cause of flatulence in higher doses.

Other Ingredients

In addition to the ingredients listed above, Gut MD includes:
  • Vegetable cellulose capsule
  • Vegetable oil powder (as a lubricant)

What Allergens Does this Product Have?


People who are allergic to crustaceans are safe to use this product since it’s 100% shellfish-free .


Celiac’s should have no problem with this product since it’s 100% gluten-free.


This product is 100% soy-free.


This product is 100% free of all preservatives.

GutMD does contain Lactose.

How to take 1MD GutMD

As a dietary supplement, take three (3) capsules, once a day, on an empty stomach with a full glass of water, or as recommended by a healthcare professional. Wait one hour before eating.

Ideally you should consult with your doctor before taking any supplement, including this one. As far as I can tell all of these enzymes do occur naturally, so they are probably quite safe. But, there may be a rare exception where you shouldn’t take this, especially if you are pregnant, nursing or trying to conceive or if you are taking medication or have had a serious illness, disease or surgery. So please check with your doctor.

Does 1MD Offer a Money Back Guarantee?

1MD offers a 100% money-back, no-questions-asked guarantee and refund for up to 90 days (minus the cost of return shipping). This is a strong statement for the consumer and longer than most supplement providers offer.

To ensure your refund, you need to call customer service at (888-393-4030) prior to returning any used or unused product. You need to include the return authorization number (RAN), which 1MD support will supply. Without the RAN, 1MD can’t process your return shipment.

Expect your refund to process in 2 to 3 weeks.

Are There Any GutMD Scams?

I checked search engines and reviewed multiple consumer-protection websites, but I can’t find evidence of any scams or problems. As always, however, you should do your own research and buy from a reputable retailer. I also recommend that buying directly from the manufacturer is the safest way to avoid a scam.

Are There Any Product Complaints?

I cannot find any alarming or serious complaints associated with Gut MD. There are a few individual reports of temporary bloating, gas, nausea, stomach pain, diarrhea, or not seeing a discernible change or improvement. The majority of reviews and customer comments are positive. However, because no product is right for all conditions and individuals, you should discuss with your healthcare provider and determine for yourself if GutMD is the right choice for you.

Again, if you have any issues with Gut MD, 1MD will issue a refund within 90 days.

Does 1MD Have Good Customer Support?

Yes, all evidence (including the company reputation, strength of guarantee, and listing of email and phone number) points to the quality and care customer support provides. I personally have not anything but good customer support.

Where to Purchase Gut MD

The best and safest way to buy 1MD GutMD is from the manufacturer directly. As an added benefit, you also have access to discounts on volume purchases and any special offers, and you are assured of receiving the authentic product–fresh and unopened.

Review Rating:

Best for: clinical-strength gut lining repair for leaky gut

Click here to buy direct (best price)

No Risk – 90 day money back guarantee

Full Reference List

  1. Van Zanten AR, Dhaliwal R, Garrel D, Heyland DK. Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis. Critical care. 2015 Dec;19(1):294.
  2. Zuhl M, Dokladny K, Mermier C, Schneider S, Salgado R, Moseley P. The effects of acute oral glutamine supplementation on exercise-induced gastrointestinal permeability and heat shock protein expression in peripheral blood mononuclear cells. Cell Stress and Chaperones. 2015 Jan 1;20(1):85-93.
  3. Ray C, Kerketta JA, Rao S, Patel S, Dutt S, Arora K, Pournami F, Bhushan P. Human Milk Oligosaccharides: The Journey Ahead. International journal of pediatrics. 2019;2019.
  4. Vázquez E, Barranco A, Ramírez M, Gruart A, Delgado-García JM, Martínez-Lara E, Blanco S, Martín MJ, Castanys E, Buck R, Prieto P. Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents. The Journal of nutritional biochemistry. 2015 May 1;26(5):455-65.
  5. Elison E, Vigsnaes LK, Krogsgaard LR, Rasmussen J, Sørensen N, McConnell B, Hennet T, Sommer MO, Bytzer P. Oral supplementation of healthy adults with 2′-O-fucosyllactose and lacto-N-neotetraose is well tolerated and shifts the intestinal microbiota. British Journal of Nutrition. 2016 Oct;116(8):1356-68.
  6. Adams CA, Gutiérrez B. The benefits of human milk oligosaccharides in adult nutrition. Nutrafoods. 2018;17:169-73.
  7. Wu YR. Characterizing effects of prebiotics and human milk oligosaccharides on the intestinal epithelial barrier (Doctoral dissertation). 2017.
  8. Newburg DS, Tanritanir AC, Chakrabarti S. Lactodifucotetraose, a human milk oligosaccharide, attenuates platelet function and inflammatory cytokine release. Journal of thrombosis and thrombolysis. 2016 Jul 1;42(1):46-55.
  9. Cho MJ, Kim JH, Park CH, Lee AY, Shin YS, Lee JH, Park CG, Cho EJ. Comparison of the effect of three licorice varieties on cognitive improvement via an amelioration of neuroinflammation in lipopolysaccharide-induced mice. Nutrition research and practice. 2018 Jun 1;12(3):191-8.
  10. Jung JC, Lee YH, Kim SH, Kim KJ, Kim KM, Oh S, Jung YS. Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease. BMC complementary and alternative medicine. 2015 Dec;16(1):19.
  11. Yang R, Wang LQ, Yuan BC, Liu Y. The pharmacological activities of licorice. Planta medica. 2015 Dec;81(18):1654-69.
  12. Calame W, Weseler AR, Viebke C, Flynn C, Siemensma AD. Gum arabic establishes prebiotic functionality in healthy human volunteers in a dose-dependent manner. British Journal of Nutrition. 2008 Dec;100(6):1269-75.
  13. Cherbut C, Michel C, Raison V, Kravtchenko T, Severine M. Acacia gum is a bifidogenic dietary fibre with high digestive tolerance in healthy humans. Microbial Ecology in Health and Disease. 2003 Jan 1;15(1):43-50.

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