Dr. Rose, M.D. (researcher)
Evan Jerkunica (writer)
Best for: Leaky Gut and Digestive Health
No Risk – 60 day money back guarantee
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GutConnect 365 by NatureMD (formerly United Naturals) is a supplement for healing leaky gut. It was formulated by Dr. Vincent Pedre, a specialist in gut health. The ingredients in GutConnect 365 have substantial research supporting their effectiveness in healing leaky gut. GutConnect 365 is a powerful leaky gut supplement with the latest scientifically proven ingredients.
Leaky gut is when your intestines have microscopic holes that let undigested food and pathogens into your blood stream. Here are potential symptoms of leaky gut (aka intestinal permeability):
If you have any of the above symptoms, there’s a good chance GutConnect 365 could help decrease your symptoms.
Now I’m going to review every ingredient…and review the research studies that show how they can help heal your leaky gut.
Now I’m going to review every single ingredient in GutConnect 365.
The following ingredients are put into this product with the intention of healing leaky gut, aka intestinal permeability.
Edward Rose M.D. looked through the clinical literature to find the best research studies on these ingredients. I am using his great work to analyze the ingredients in this product to see if they make sense.
In times of stress – both acute or chronic, the body can’t manufacture sufficient L-Glutamine to cover needs, so supplementation can be beneficial.
Quercetin dihyrate is an easily absorbed antioxidant that has been clinically studied.B1 Quercetin is effective at soaking up free radicals that cause oxidative damage to proteins. Keep in mind that our intestines have proteins that need protecting from oxidative damage.
This ingredient will likely prevent damage to our gut lining proteins. And with less destruction of our intestines, our body can direct more resources to repairing permeability in our gut…making it less leaky and more solid.
Quercetin dihyrate also protects the kidneys in rat studies.B2 So it’s a good bet that human kidneys are protected by quercetin dihyrate as well.
Slippery elm bark has been shown to help with constipation and diarrhea. In a small study for both constipative irritable bowel syndrome (IBS-C), as well as alternating diarrhea & constipative IBS (IBS-M).C1 Slippery elm has also been shown to have antioxidant properties in-vitro.C2
Slippery elm is traditionally considered a gut soothing compound useful for treating stomach ulcers. Ulcer treatment by slippery elm has been proven in horses,C3 but I would bet that it’s effective in humans as well.
Marshmallow root has been proven to repair leaky gut. It repairs leaky gut by stimulating the growth of intestinal cells, called epithelial cells. The study also showed that marshmallow form a protective layer for the epithelial cells – preventing future leaky gut damage.D1
Marshmallow root has been used medicinally since at least the Ancient Greeks. In the middle ages it was used to soothe stomach ailments.D2
Marshmallow root may even play a role in improving immune response and fighting autoimmune disorders.D3
This is a monosaccharide abbreviated GlcNAc. Derived from glucose, it helps form cell walls in bacteria when crosslinked with other polymers and peptides. In humans, it combines with glucuronic acid to form hyaluronic acid, a major component of cells walls, collagen, and cartilage. There may be some immunomodulatory effects via inhibition of elastase release from white blood cells.
Glucosamine is widely used for the treatment and prevention of osteoarthritis, although its mechanism of action is poorly understood. According to a study by Kubomura, GlcNAc improves cartilage health as indicated by biomarkers of cartilage growth and turnover. Another paper by the same author showed that glucosamine was chondroprotective, reducing inflammation in the joint and destruction of chondrocytes. More recently, Lee reported that GlcNAc downregulates T-helper cells, reducing the autoimmune aspects of multiple sclerosis.
Licorice root has been used to treat digestive disorders since the Ancient Egyptians. F1
The mechanisms for deglycyrrhizinated licorice’s leaky gut beneficial effects are likely 3 fold:F2
***A quick note*** – deglycyrrhizinated licorice root is not thought to affect blood pressure like plain licorice root extract does.source Of course you should still check with your doctor when you have health conditions before taking a supplement.
At the dose of 50mg like in this product, aloe vera extract is a mild laxative. It has been used as a laxative for thousands of years.G1 There is limited research showing that it may help with digestive issues like IBS,G2 and it may encourage your native probiotics to thrive.G3
So in this product at this dose, I think this ingredient helps keep reduce constipation, and it supports native probiotic populations. It’s safe to say that aloe vera likely indirectly supports healing of leaky gut.
Stable blood sugar causes our bodies to spend more time in a healing (parasympathetic) state – which helps repair leaky gut. The anti-viral effects are also indirectly good for general healing.
Zinc orotate is a more easily absorbable form of zinc. And zinc has been shown to improve leaky gut in a number of highly cited research studies.
Zinc has been shown to decrease leaky gut in children with diarrhea.I1 It has also been shown to decrease leakiness of tight junctions. I2 With zinc supplementation, guinea pigs and rats also had decreased intestinal permeability.
The scientific evidence is quite strong for zinc helping heal leaky gut!
Besides the ingredients included for helping heal leaky gut, there are a few other ingredients. These ingredients are responsible for the taste, easy mixing into water, and sweetness of the drink.
The natural flavors are responsible for the vanilla and cinnamon flavor of the drink.
Stevia is a natural sweetener that causes no increase in blood sugar.3 Using this sweetener keeps this product sugar free, and low in calories.
Here’s how it tastes:
I often crave the taste, and look forward to drinking it each day. As soon as GutConnect is available to the public, I’m buying 3 bottles of this product for the taste…it’s so good, and it helps repair leaky gut.
NatureMD made GutConnect 365 safe for people with food most allergies or sensitives. Here are all
Leaky gut is common in those allergic to gluten or wheat. So the interest in GutConnect in the Celiac community should be high. Thankfully, my gluten free friends can use this product without any problems.
This product contains no diary or lactose. People with dairy allergies are 100% okay to use this daily.
This is a soy free and egg free product. So you’re good there!
The MCT oil is made from coconut, which is a tree nut. So this product isn’t for you if you don’t tolerate tree nuts well.
Previous versions of this product had traces of shellfish. But all traces of shellfish has been removed.
I’m told future this product is working on organic certification. But the certification process hasn’t completed yet, and ingredient changes may or may not be needed. So stay tuned!
The starting dosage for Sybiotic 365 is 1 scoop in 8 oz of water per day. I like to take this as a tasty drink between meals – between breakfast and lunch. I also use 12 oz of water for my taste buds.
Yes – NatureMD has a 60 day, money back guarantee.
I really respect companies that give a money back guarantee. That shows that the company believes 100% in their product. And for you, there is no risk in trying this product.
The internet is a big place, and there is always a chance people are counterfeiting the product or running another type of scam. To avoid any chance of scams, buy directly from the company at www.NatureMD.com
I haven’t seen anything, but I will keep a lookout and report it here.
Yes! I thought their phone support was especially good. Here is a link to their support page. It is equally good support as United Naturals, the former name of NatureMD.
The best place to purchase this product is direct from the manufacturer. They typically have good discounts for buying multiple bottles.
Best for: Leaky Gut and Digestive Health
No Risk – 60 day money back guarantee
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