Review of GutConnect 365 from United Naturals

Review Rating:

Best for: Leaky Gut and Digestive Health

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Transparency disclosure: for each person who buys GutConnect 365 by clicking a link on this page, receives a small percentage of the sale. We would strongly recommend this product without compensation, but I want you to know all the potential motivations for writing this review. Transparency rules!

Review Summary

GutConnect 365 by United Naturals is a supplement for healing leaky gut. It was formulated by Dr. Vincent Pedre, a specialist in gut health. The ingredients in GutConnect 365 have substantial research supporting their effectiveness in healing leaky gut. GutConnect 365 is a powerful leaky gut supplement with the latest scientifically proven ingredients.

Video Review of 1MD’s Probiotic

What is leaky gut?

Leaky gut is when your intestines have microscopic holes that let undigested food and pathogens into your blood stream. Here are potential symptoms of leaky gut (aka intestinal permeability):

  • chronic diarrhea
  • constipation
  • gas or bloating
  • nutritional deficiencies
  • compromised immune function
  • arthritis or joint pain

If you have any of the above symptoms, there’s a good chance GutConnect 365 could help decrease your symptoms.

Now I’m going to review every ingredient…and review the research studies that show how they can help heal your leaky gut.

Ingredients in Gut Connect 365

synbiotic 365 ingredients updated

Now I’m going to review every single ingredient in GutConnect 365.

Active Ingredients

The follow ingredients are put into this product with the intention of healing leaky gut, aka intestinal permeability.

Edward Rose M.D. looked through the clinical literature to find the best research studies on these ingredients. I am using his great work to analyze the ingredients in this product to see if they make sense.


L-Glutamine has been shown to help repair the intestinal epithelial lining.A1,A2. That is a fancy way to say that it helps repair leaky gut.

In times of stress – both acute or chronic, the body can’t manufacture sufficient L-Glutamine to cover needs, so supplementation can be beneficial.

There is also evidence that L-Glutamine helps build and maintain muscle mass.A3 This is especially true as we age,A4 or if our digestion gets compromised.

Quercetin Dihyrate

Quercetin dihyrate is an easily absorbed antioxidant that has been clinically studied.B1 Quercetin is effective at soaking up free radicals that cause oxidative damage to proteins. Keep in mind that our intestines have proteins that need protecting from oxidative damage.

This ingredient will likely prevent damage to our gut lining proteins. And with less destruction of our intestines, our body can direct more resources to repairing permeability in our gut…making it less leaky and more solid.

Quercetin dihyrate also protects the kidneys in rat studies.B2 So it’s a good bet that human kidneys are protected by quercetin dihyrate as well.

Slippery Elm Bark

Slippery elm bark has been shown to help with constipation and diarrhea. In a small study for both constipative irritable bowel syndrome (IBS-C), as well as alternating diarrhea & constipative IBS (IBS-M).C1 Slippery elm has also been shown to have antioxidant properties in-vitro.C2

Slippery elm is traditionally considered a gut soothing compound useful for treating stomach ulcers. Ulcer treatment by slippery elm has been proven in horses,C3 but I would bet that it’s effective in humans as well.

Organic Marshmallow Root

Marshmallow root has been proven to repair leaky gut. It repairs leaky gut by stimulating the growth of intestinal cells, called epithelial cells. The study also showed that marshmallow form a protective layer for the epithelial cells – preventing future leaky gut damage.D1

Marshmallow root has been used medicinally since at least the Ancient Greeks. In the middle ages it was used to soothe stomach ailments.D2

Marshmallow root may even play a role in improving immune response and fighting autoimmune disorders.D3

N-Acetyl Glucosamine

This is a monosaccharide abbreviated GlcNAc. Derived from glucose, it helps form cell walls in bacteria when crosslinked with other polymers and peptides. It is also a component of the hard exterior shells of certain insects and crustaceans. In humans, it combines with glucuronic acid to form hyaluronic acid, a major component of cells walls, collagen, and cartilage. There may be some immunomodulatory effects via inhibition of elastase release from white blood cells.

Glucosamine is widely used for the treatment and prevention of osteoarthritis, although its mechanism of action is poorly understood. According to a study by Kubomura, GlcNAc improves cartilage health as indicated by biomarkers of cartilage growth and turnover. Another paper by the same author showed that glucosamine was chondroprotective, reducing inflammation in the joint and destruction of chondrocytes. More recently, Lee reported that GlcNAc downregulates T-helper cells, reducing the autoimmune aspects of multiple sclerosis.

Licorice root extract (deglycrrhizinated)

Licorice root has been used to treat digestive disorders since the Ancient Egyptians. F1

The mechanisms for licorice’s leaky gut beneficial effects are likely 3 fold:F2

  • antioxidant
    • Further leaky gut damage can be prevented by the antioxidant properties of licorice root extract.
  • antimicrobal
    • Decreasing the pathogens in our intestines can decrease leaky gut by giving more territory back to probiotics which help decrease intestinal permeability.F3
  • immunoregulatory
    • One symptom of leaky gut is arthritic symptoms, which are likely part of an autoimmune problem. This problem may be improved by the immunoregulatory properties of licorice root extract.

Aloe Vera Extract

At the dose of 50mg like in this product, aloe vera extract is a mild laxative. It has been used as a laxative for thousands of years.G1 There is limited research showing that it may help with digestive issues like IBS,G2 and it may encourage your native probiotics to thrive.G3

So in this product at this dose, I think this ingredient helps keep reduce constipation, and it supports native probiotic populations. It’s safe to say that aloe vera likely indirectly supports healing of leaky gut.

Maitake Mushroom Extract

Maitake mushroom extract shows evidence of being antiviralH2 as well as blood sugar stabilizing.H3

Stable blood sugar causes our bodies to spend more time in a healing (parasympathetic) state – which helps repair leaky gut. The anti-viral effects are also indirectly good for general healing.

Zinc Orotate

Zinc orotate is a more easily absorbable form of zinc. And zinc has been shown to improve leaky gut in a number of highly cited research studies.

Zinc has been shown to decrease leaky gut in children with diarrhea.I1 It has also been shown to decrease leakiness of tight junctions. I2 With zinc supplementation, guinea pigs and rats also had decreased intestinal permeability.

The scientific evidence is quite strong for zinc helping heal leaky gut!

Other Ingredients

Besides the ingredients included for helping heal leaky gut, there are a few other ingredients. These ingredients are responsible for the taste, easy mixing into water, and sweetness of the drink.

Natural Flavors

The natural flavors are responsible for the vanilla and cinnamon flavor of the drink.

MCT Oil Powder

The MCT oil powder makes the drink blend better. MCT oil also has been shown to help with heart health and weight loss.1,2

Rebaudioside A (Stevia Leaf Extract)

Stevia is a natural sweetener that causes no increase in blood sugar.3 Using this sweetener keeps this product sugar free, and low in calories.

How Does It Taste?

Here’s how it tastes:

  • Vanilla cinnamon flavor
    • Most products stick to plain chocolate or vanilla. But GutConnect 365 has a unique blend of vanilla and cinnamon that really works well.
  • Not overly sweet (sugar-free)
    • They use a sugar free, stevia extract for sweetness. I like to blend it in about 12 oz of water so it makes it the perfect sweetness. The licorice root extract probably contributes to the sugar-free sweetness as well.
  • Smooth mouth feel – blends well – not chalky
    • It’s very smooth, and has none of the chalkiness that lots of health drinks have.

I often crave the taste, and look forward to drinking it each day. As soon as GutConnect is available to the public, I’m buying 3 bottles of this product for the taste…it’s so good, and it helps repair leaky gut.

GutConnect 365 Allergen Information

United Naturals made GutConnect 365 safe for people with food most allergies or sensitives. Here are all

Perfect for Individuals with Celiac Disease

Leaky gut is common in those allergic to gluten or wheat. So the interest in GutConnect in the Celiac community should be high. Thankfully, my gluten free friends can use this product without any problems.

GutConnect 365 is Dairy Free

This product contains no diary or lactose. People with dairy allergies are 100% okay to use this daily.

No Soy or Eggs

This is a soy free and egg free product. So you’re good there!

Contains Tree Nuts

The MCT oil is made from coconut, which is a tree nut. So this product isn’t for you if you don’t tolerate tree nuts well.

Contains Shell Fish

Future versions of this product will likely remove the shellfish – so stay tuned.

GutConnect 365 is GMO Free

I’m told future this product is working on organic certification. But the certification process hasn’t completed yet, and ingredient changes may or may not be needed. So stay tuned!

What Is The GutConnect 365 Starting Dosage?

The starting dosage for Sybiotic 365 is 1 scoop in 8 oz of water per day. I like to take this as a tasty drink between meals – between breakfast and lunch. I also use 12 oz of water for my taste buds.

Do They Offer A Money Back Guarantee?

Yes – United Naturals has a 60 day, money back guarantee.

I really respect companies that give a money back guarantee. That shows that the company believes 100% in their product. And for you, there is no risk in trying this product.

Are There AnyGut Connect 365 Scams?

The internet is a big place, and there is always a chance people are counterfeiting the product or running another type of scam. To avoid any chance of scams, buy directly from the company at

Any Product Complaints?

I haven’t seen anything, but I will keep a lookout and report it here.

Does United Naturals Have Good Customer Support?

Yes – here is their support email:

Where Can You Purchase GutConnect 365?

The best place to purchase this product is direct from the manufacturer. They typically have good discounts for buying multiple bottles.

Review Rating:

Best for: Leaky Gut and Digestive Health

Click here to buy direct (best price)

No Risk – 60 day money back guarantee

29 comments on “GutConnect 365 Review – Leaky Gut Supplement by United Naturals” - Click here to write your comment

  1. Patti Spoeth says:

    What is the difference between GutConnect365 and Synbiotic365?

    • evan says:

      Hi Patti,

      Each product works on different parts of the digestive process.

      Synbiotic 365 – this helps people who have problem with their probotic bacteria in their intestines. There are over a hundred different health issues that have been tied to your probiotic bacteria — so it’s important to make sure they are as healthy as possible down there!

      GutConnect 365 – this helps people who have intestinal permeability problems – aka holes in their intestines. That means that they will let things into your blood stream from your intestines that shouldn’t be there. That can be anything from undigested food, to pathogens into your blood stream. The symptoms of leaky gut can be anything from diarrhea to brain fog to arthritic symptoms.

      I hope that clears things up.

      To your health,
      Evan Jerkunica

  2. Suzanne says:

    I am allergic to caffeine. Does this product contain caffeine?

  3. Karen says:

    Love the taste of this. Can i mix it with boiling water to make a hot drink?

    • evan says:

      Hi Karen,

      I would not recommend that if you want to get the benefits from the amino acids. I believe the amino acids are broken down in hot water. I’ll triple check that I’m correct and I’ll email you if I need to revise this answer.

      To your health,
      Evan Jerkunica

  4. Mary says:

    I am diabetic and my husband has congestive heart failure. Will we still be able to use this product?


  5. Mary says:

    Just tried GutConnect 365 -1 scoop w 8 oz water. Love the cinnamon flavor and easy to mix in my drink shaker. I will look forward to drinking it daily.
    Feeling like I’m “treating” myself to something SPECIAL?
    Now excited for noticeable results!!

  6. Roz says:

    Can I take vitamin b12 and probiotics with Gut Connect 365, or is that not necessary?

    • evan says:

      Hi Roz,

      Gut Connect 365 does not have B12 or probiotics.

      So I’d assume it’s fine to take both together.

      But, you always want to check with your doctor before you take a supplement in case you have complicated health conditions.

      To your health,
      Evan Jerkunica

  7. Dorothy says:

    How many times do you drink this 8oz drink a day?

  8. Maureen says:

    can you tell me the amount of calories per serving this product has?

    • evan says:

      Hi Maureen,

      Each scoop has 20 calories.

      The calories come from L-glutamine (amino acid – components of protein), and also MCT oil (which is a fat). This study, and this study show that MCT oil has some weight loss benefits if you’re interested.

      To your health,
      Evan Jerkunica

  9. Ann says:

    Can you take this product if you’re allergic to cinnamon and peanuts? It has a cinnamon flavor.

  10. Mildred Silva says:

    Hi. Can this be mixed with almond milk?

  11. Judy Maness says:

    Is it possible that this product helps with bile elimination? Seems to be helping me.

  12. Janie Andrews says:

    I received my gut connect & been on it for 5 days. I immediately noticed I didn’t feel bloated after eating. I already feel better. Looking for to the long term benefits ?

  13. S Gladish says:

    Show the product be taken with or without food?

    • evan says:

      Hi S Gladish,

      I would take it on an empty stomach. Ideally first thing in the morning before breakfast, or between meals.

      To your health,
      Evan Jerkunica

  14. S Gladish says:

    Thank you for your reply, as well as your fine review! Evan.
    Love the taste, texture and mix ability

  15. Sarah says:

    Can I take the Gut Connect 365 & the Snybiotic 365 at the same time?

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